Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025;33(1):47-49.
doi: 10.5455/aim.2024.33.47-49.

Association Between rs243866 Polymorphism of the MMP-2 Gene and Target Organ Damage in Patients with Uncontrolled Hypertension

Huynh Thi Ngoc Giau  1 , Tran Viet An  1 , Trinh Thi Hong Cua  1 , Bui The Dung  1   2
Affiliations

Association Between rs243866 Polymorphism of the MMP-2 Gene and Target Organ Damage in Patients with Uncontrolled Hypertension

Huynh Thi Ngoc Giau et al. Acta Inform Med. 2025.

Abstract

Background: Uncontrolled hypertension (UHT) is associated with an increased risk of target organ damage (TOD). Matrix metalloproteinase-2 (MMP-2) plays a role in vascular remodeling, and the rs243866 (-1575G/A) polymorphism has been implicated in cardiovascular diseases.

Objective: This study aimed to evaluate the association between rs243866 and TOD in UHT patients.

Methods: A cross-sectional study was conducted on 134 UHT patients at two hospitals in Vietnam. Genotyping of rs243866 was performed using PCR, and TOD was assessed via echocardiography (left ventricular hypertrophy - LVH), renal function tests (eGFR, albuminuria), and carotid ultrasound (carotid atherosclerosis).

Results: The genotypic distribution was GG (79.9%), GA (18.6%), and AA (1.5%), with allele frequencies of 89.2% (G) and 10.8% (A). The A allele was associated with higher risks of LVH (OR=2.553, 95% CI: 1.052-6.196, p=0.035), CKD (OR=2.639, 95% CI: 0.986-7.066, p=0.048), and carotid atherosclerosis (OR=6.806, 95% CI: 2.203-21.024, p<0.001). These associations remained significant after adjusting for confounders.

Conclusion: The rs243866 polymorphism of MMP-2 is independently associated with TOD in UHT, particularly LVH, CKD, and carotid atherosclerosis. Genetic screening for rs243866 may provide insights into risk stratification and personalized hypertension management.

Keywords: Carotid Atherosclerosis; Chronic Kidney Disease; Left Ventricular Hypertrophy; MMP-2; Target Organ Damage; Uncontrolled Hypertension; rs243866.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

References

    1. Lancet: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1923–1994. - PMC - PubMed
    1. Ferdinand KC, Harrison D, Johnson A. The new-hope study and emerging therapies for difficult-to-control and resistant hypertension. Prog Cardiovasc Dis. 2020;63(1):64–73. - PubMed
    1. Bisogni V, Cerasari A, Pucci G. Matrix Metalloproteinases and Hypertension-Mediated Organ Damage: Current Insights. Integr Blood Press Control. 2020;13:157–169. - PMC - PubMed
    1. Ritter AMV, de Faria AP, Barbaro NR, et al. The rs243866/243865 polymorphisms in MMP-2 gene and the relationship with BP control in obese resistant hypertensive subjects. Gene. 2018;646:129–135. - PubMed
    1. Sabbatini AR, Barbaro NR, de Faria AP, et al. Matrix metalloproteinase-2 -735C/T polymorphism is associated with resistant hypertension in a specialized outpatient clinic in Brazil. Gene. 2017;620:23–29. - PubMed

LinkOut - more resources