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. 2025 Apr;20(2):1386-1388.
doi: 10.1016/j.jds.2023.11.012. Epub 2023 Nov 27.

Refractory gingival pyogenic granuloma treated with wide excision

Jyh-Kwei Chen  1 , Meng-Ling Chiang  2   3   4
Affiliations

Refractory gingival pyogenic granuloma treated with wide excision

Jyh-Kwei Chen et al. J Dent Sci. 2025 Apr.
No abstract available

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Conflict of interest statement

Th authors have no conflicts of interest relevant to this article.

Figures

Fig. 1
Figure 1
Clinical photographs, radiographs, a gross photograph of the surgical specimens, and histopathological microphotographs of our patient with refractory pyogenic granuloma. (A) During the patient’s local excision period, the tumor recurred after each observation, with the tumor size remaining the same or even larger than the original. After four recurrences and four unsuccessful local excisions, the fifth surgery, which involved wide excision, led to the patient’s recovery, with no recurrence over six months. (B) A deep red, smooth-surfaced tumor was observed on the mesial and buccal gingiva of the left mandibular second molar, measuring 1.7 cm × 1.1 cm. (C) The periapical radiography revealed no signs of periodontal bone loss or periapical pathosis in the area of the left mandibular second molar, and the teeth showed no carious lesions. (D) The wide excision specimen exhibited a 4 mm safe margin surrounding the tumor, while there was no safe margin on the left side of the specimen since the tumor extended directly to the free gingival margin, leaving no additional normal tissue for excision. (E) A low-power view of the patient’s pathological tissue section exhibited lobules of capillary proliferation with an inflammatory cells infiltrate (H&E stain, original magnification 10x). (F) A high-power view of the tumor revealed lobules of capillary proliferation and branching blood vessel formation (H&E stain, original magnification 40x). (G) There was no recurrence six months after the wide surgical excision, although complications such as gingival loss and root exposure were observed. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
See this image and copyright information in PMC

References

    1. Vilmann A., Vilmann P., Vilmann H. Pyogenic granuloma: evaluation of oral conditions. Br J Oral Maxillofac Surg. 1986;24:376–382. - PubMed
    1. Kamal R., Dahiya P., Puri A. Oral pyogenic granuloma: various concepts of etiopathogenesis. J Oral Maxillofac Pathol. 2012;16:79. - PMC - PubMed
    1. Jafarzadeh H., Sanatkhani M., Mohtasham N. Oral pyogenic granuloma: a review. J Oral Sci. 2006;48:167–175. - PubMed
    1. Saravana G. Oral pyogenic granuloma: a review of 137 cases. Br J Oral Maxillofac Surg. 2009;47:318–319. - PubMed
    1. Al-Noaman A.S. Pyogenic granuloma: clinicopathological and treatment scenario. J Indian Soc Periodontol. 2020;24:233. - PMC - PubMed

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