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Review
. 2025 Mar 19;5(2):oeaf022.
doi: 10.1093/ehjopen/oeaf022. eCollection 2025 Mar.

Spontaneous coronary artery dissection in regions of non-Western populations: a systematic literature search and scoping review

Rasha Kaddoura  1 , Ashraf Ahmed  2 , Mohammed Al-Hijji  3 , Fathima Aaysha Cader  4   5 , Mirvat Alasnag  6 , David Adlam  7
Affiliations
Review

Spontaneous coronary artery dissection in regions of non-Western populations: a systematic literature search and scoping review

Rasha Kaddoura et al. Eur Heart J Open. .

Abstract

Current data on spontaneous coronary artery dissection (SCAD) predominantly originate from Europe or Caucasians with limited information about other ethnicities. This scoping review presents the evidence on SCAD in non-Western countries. The prevalence of SCAD diagnosis was 1.0% [95% confidence interval (95% CI): 0.0-3.0, I 2 = 99%] among patients presenting with myocardial infarction, increasing to 5.0% (95% CI: 1.0-16.0, I 2 = 99%) among females. The mean age was 51.3 years with females accounting for 54.0% of patients. A conservative revascularization management was reported in 48.0% (95% CI: 32.0-65.0, I 2 = 85%) of patients. Antiplatelet therapy was reported as dual (68.0%, 95% CI: 37.0-89.0, I 2 = 90%) in only three studies. A death rate (3.0%) was similar during hospitalization and at mean follow-up of 23.42 months. In conclusion, there is a marked variability in the clinical course of patients with SCAD as well heterogeneity among the included studies. This review identified knowledge gaps in our understanding of SCAD in non-Western countries that should be addressed in future prospective studies.

Keywords: False lumen; Intima; MENA; Scaffold; South Asia.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Graphical Abstract
Graphical Abstract
Figure 1
Figure 1
Timeline of the included studies.
See this image and copyright information in PMC

References

    1. Yip A, Saw J. Spontaneous coronary artery dissection—A review. Cardiovasc Diagn Ther 2015;5:37–48. - PMC - PubMed
    1. Adlam D, Alfonso F, Maas A. Vrints C; Writing Committee. European Society of Cardiology, Acute Cardiovascular Care Association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur Heart J 2018;39:3353–3368. - PMC - PubMed
    1. Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ. Spontaneous coronary artery dissection: current state of the science: a scientific statement from the American Heart Association. Circulation 2018;137:e523–e557. - PMC - PubMed
    1. Saw J, Mancini GBJ, Humphries KH. Contemporary review on spontaneous coronary artery dissection. J Am Coll Cardiol 2016;68:297–312. - PubMed
    1. Eleid MF, Guddeti RR, Tweet MS, Lerman A, Singh M, Best PJ, Vrtiska TJ, Prasad M, Rihal CS, Hayes SN, Gulati R. Coronary artery tortuosity in spontaneous coronary artery dissection: angiographic characteristics and clinical implications. Circ Cardiovasc Interv 2014;7:656–662. - PubMed