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Editorial
. 2025 Jan 10;10(3):657-659.
doi: 10.1016/j.ekir.2025.01.005. eCollection 2025 Mar.

Progression of HIV-1 CKDs: Viral Load Versus APOL1 Risk Alleles

Patricio E Ray  1
Affiliations
Editorial

Progression of HIV-1 CKDs: Viral Load Versus APOL1 Risk Alleles

Patricio E Ray. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
HIV-1 and the APOL1 risk alleles interact to precipitate the progression of HIV-CKD in Black adults on ART. Carriers of 2 copies of the APOL1 risk alleles with higher viral loads showed more significant proteinuria and estimated GFR declines and may have the highest long-term risk for developing hypertension and/or CVD in association with the progression of HIV-CKD. Carriers of a single copy of the G1 risk allele with higher viral loads showed more significant GFR declines when compared with those with sustained viral suppression. It remains unclear whether carriers of a single copy of the G2 risk allele will show similar outcomes than carriers of 1 copy of the G1 risk allele. People coinheriting the APOL1 p.N264 missense variant with either 2 or 1 copy of the G2 allele may have a similar risk of CKD than those carrying 2 copies of the APOL1-G0 alleles. ART, antiretroviral therapy; CKD, chronic kidney disease; CVD, cardiovascular disease; GFR, glomerular filtration rate; HTN, hypertension.
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References

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