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Review
. 2025 Mar 15;17(3):1604-1612.
doi: 10.62347/TVTB3045. eCollection 2025.

Advances in diagnosis and treatment of lymphoma-associated hemophagocytic syndrome

Fuli Fan  1 , Jian Liu  1 , Shanshan Liu  1 , Yujie Xu  1 , Xiaolin Wang  2 , Yuting Yan  3 , Zhiqun Zhang  4
Affiliations
Review

Advances in diagnosis and treatment of lymphoma-associated hemophagocytic syndrome

Fuli Fan et al. Am J Transl Res. .

Abstract

Hemophagocytic syndrome (HPS) is a rare clinical disorder characterized by persistent and ineffective activation of the immune system, leading to a severe systemic inflammatory response. Lymphoma-associated hemophagocytic syndrome (LAHS) refers to HPS caused either by lymphoma itself or by immunosuppression during lymphoma chemotherapy at present, there is no standardized consensus on the diagnosis and treatment of LAHS, both domestically and internationally. After remission induced by combination chemotherapy, hematopoietic stem cell transplantation (HSCT) is a commonly used treatment approach. This paper reviews the latest advancements in the diagnosis and treatment of LAHS, providing a reference for its clinical management.

Keywords: Lymphoma-associated hemophagocytic syndrome; diagnosis; pathogenesis; prognosis; treatment.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Pathological and physiological processes of lymphoma-associated hemophagocytic syndrome. HPS, Hemophagocytic syndrome; LAHS, Lymphoma-associated hemophagocytic syndrome; pHLH, primary hemophagocytic lymphohistiocytosis; sHLH, secondary HLH.
Figure 2
Figure 2
Signal pathway diagram of HLH pathological process. CSF, cerebrospinal fluid; HLH, hemophagocytic lymphohistiocytosis.
See this image and copyright information in PMC

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