Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr;77(4):2009-2012.
doi: 10.1007/s12070-025-05439-y. Epub 2025 Mar 27.

B-Cell Lymphoma: A Malignant Transformation From Unicentric Castleman Disease Of The Parotid Gland

Kok Foong Yuen  1   2 , Rohaizam Japar  2 , Zakinah Yahaya  2 , Farah Hani Hassan  2 , Irfan Mohamad  1
Affiliations

B-Cell Lymphoma: A Malignant Transformation From Unicentric Castleman Disease Of The Parotid Gland

Kok Foong Yuen et al. Indian J Otolaryngol Head Neck Surg. 2025 Apr.

Abstract

Castleman disease is a heterogeneous group of lymphoproliferative disorders and can be categorized into unicentric Castleman disease and multicentric Castleman disease. Malignant transformation is also known to occur in the multicentric variant, however, it is rarely known to transpire in the unicentric type. The objective of this case report is to highlight the occurrence of malignant transformation into a unicentric Castleman disease of the parotid gland. We report a 25-year-old gentleman with a history of unicentric Castleman disease of the left parotid gland post excision, presented with a left parotid swelling for 4 years. The initial cytology report yielded a diagnosis of recurrent Castleman Disease. The patient successfully underwent a total parotidectomy and left modified radical neck dissection. Final histopathological reported it to be a B-cell lymphoma. The patient was referred to our Hematology colleague for initiation of treatment. The reported case showcased the importance of taking into consideration malignant transformation in unicentric Castleman disease even though it was reported to be a rare occurrence.

Keywords: B-cell lymphoma; Castleman disease; Parotid gland; Unicentric.

PubMed Disclaimer

Conflict of interest statement

Conflict of interestNeither has there been financial support received nor conflict of interest by any of the authors in the preparation of this manuscript.

References

    1. Dispenzieri A, Fajgenbaum DC (2020) Overview of Castleman disease. Blood 135(16):1353–1364. 10.1182/blood.2019000931 - PubMed
    1. Lomas OC et al (2021) The management of Castleman disease. Br J Haematol 195(3):328–337. 10.1111/bjh.17688 - PubMed
    1. Newlon JL, Couch M, Brennan J (2007) Castleman’s disease: three case reports and a review of the literature. Ear Nose Throat Journal 86(7):414–418. 10.1177/014556130708600721 - PubMed
    1. Komaranchath A, Jacob L (2015) Unicentric Castleman’s disease: an unusual cause of neck swelling. J Case Rep Images Oncol 1:1. 10.5348/z10-2015-2-cr-2
    1. Pribyl K et al (2021) Castleman disease: A single-center case series. Int J Surg Case Rep 105650 [online] 80. 10.1016/j.ijscr.2021.105650 - PMC - PubMed