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. 2025 Apr 14;27(1):84.
doi: 10.1007/s11886-024-02186-4.

Cardiovascular Outcomes After Acute Coronary Syndrome in Persons Living with HIV: A Scoping Review

David Iskhakov  1 , Julie N Deleger  2 , Jorge Plutzky  3   4 , Virginia A Triant  1   4   5   6 , Emily P Hyle  7   8   9   10
Affiliations

Cardiovascular Outcomes After Acute Coronary Syndrome in Persons Living with HIV: A Scoping Review

David Iskhakov et al. Curr Cardiol Rep. .

Abstract

Purpose of review: Over the past twenty-five years, a growing body of research has investigated outcomes after an acute coronary syndrome (ACS) event in persons with HIV (PWH). In this scoping review, we assessed the published literature on outcomes after a prior ACS event in PWH compared to persons without HIV (PWoH) in the US and Europe.

Recent findings: Of 27 studies of secondary prevention of cardiovascular disease, 15 studies found a greater incidence of recurrent ACS, heart failure, in-stent thrombosis, revascularization, restenosis, and mortality in PWH after a prior ACS event compared to PWoH. PWH were more likely to present with STEMI, less likely to receive percutaneous coronary intervention, and more likely to exhibit an active inflammatory state. The remaining 12 studies found no significant difference in outcomes after a prior ACS event. PWH may face an increased risk of adverse outcomes after ACS that differ in presentation and management compared with PWoH. Larger observational studies are needed to assess outcomes after a prior ACS event in PWH compared to PWoH and improve clinical management.

Keywords: Acute coronary syndrome; Cardiovascular Outcomes; Human immunodeficiency virus; Persons living with HIV.

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Conflict of interest statement

Declarations. Human and Animal Rights and Informed Consent: No animal or human subjects by the authors were used in this study. Competing Interests: Jorge Plutzky reports consulting fees from Altimmune, Amgen, Boehringer Ingelheim, Esperion (clinical trial steering committee), Merck, New Amsterdam, Novo Nordisk (clinical trial steering committee, consultant), and Pfizer, outside the submitted work. Jorge Plutzky also reports grant support from Boehringer Ingelheim and Novartis, outside the submitted work. Emily P. Hyle reports personal fees from UpToDate, outside the submitted work. The other authors declare that they have no conflict of interest.

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