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. 2025 Sep 1;82(9):879-880.
doi: 10.1001/jamaneurol.2025.0639.

The Risk of Alzheimer Disease in APOE4 Homozygotes

Affiliations

The Risk of Alzheimer Disease in APOE4 Homozygotes

Eric M Reiman et al. JAMA Neurol. .
No abstract available

Plain language summary

This Viewpoint discusses the risk of Alzheimer disease in APOE4 homozygotes.

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References

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    1. Reiman EM, Arboleda-Velasquez JF, Quiroz YT, et al. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020;11(1):667. - PMC - PubMed
    1. Jansen WJ, Janssen O, Tijms BM, et al. Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. JAMA Neurol. 2022;79(3):228–243. - PMC - PubMed
    1. Farrer LA, Cupples LA, Haines JL, et al. Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis. JAMA. 1997;278(16):1349–1356. - PubMed
    1. Fortea J, Pegueroles J, Alcolea D, et al. APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease. Nat Med. 2024;30(5):1284–1291. - PubMed

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