The Risk of Alzheimer Disease in APOE4 Homozygotes
- PMID: 40227662
- PMCID: PMC12439451
- DOI: 10.1001/jamaneurol.2025.0639
The Risk of Alzheimer Disease in APOE4 Homozygotes
Plain language summary
This Viewpoint discusses the risk of Alzheimer disease in APOE4 homozygotes.
References
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- Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science. 1993;261(5123):921–923. - PubMed
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- Farrer LA, Cupples LA, Haines JL, et al. Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis. JAMA. 1997;278(16):1349–1356. - PubMed
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- Fortea J, Pegueroles J, Alcolea D, et al. APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease. Nat Med. 2024;30(5):1284–1291. - PubMed
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