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. 2025 Apr 15;151(15):1126-1129.

doi: 10.1161/CIRCULATIONAHA.124.073693. Epub 2025 Apr 14.

G-Protein-Coupled Estrogen Receptor 1 and Pregnancy Confer Protection Against Hypertension in Older Females

Affiliations

Affiliations

¹ Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).
² Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (R.N.A.).
³ Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (O.M.P.).

^# Contributed equally.

PMID: 40228067
PMCID: PMC11999251 (available on 2026-04-15)
DOI: 10.1161/CIRCULATIONAHA.124.073693

G-Protein-Coupled Estrogen Receptor 1 and Pregnancy Confer Protection Against Hypertension in Older Females

Ravneet Singh et al. Circulation. 2025.

. 2025 Apr 15;151(15):1126-1129.

doi: 10.1161/CIRCULATIONAHA.124.073693. Epub 2025 Apr 14.

Affiliations

¹ Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN (R.S., S.K., V.L.N., E.A.A., C.J.U., C.R.-C., E.Y.G.).
² Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (R.N.A.).
³ Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston (O.M.P.).

^# Contributed equally.

PMID: 40228067
PMCID: PMC11999251 (available on 2026-04-15)
DOI: 10.1161/CIRCULATIONAHA.124.073693

No abstract available

Keywords: aging; aldosterone; blood pressure; kidney; sodium.

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Conflict of interest statement

None.

References

1. Feldman RD; Gros R; Ding Q; Hussain Y; Ban MR; McIntyre AD; Hegele RA A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women. Br J Clin Pharmacol 2014, 78 (6), 1441–1452. - PMC - PubMed
1. Gohar EY; Daugherty EM; Aceves JO; Sedaka R; Obi IE; Allan JM; Soliman RH; Jin C; De Miguel C; Lindsey SH; et al. Evidence for G-Protein-Coupled Estrogen Receptor as a Pronatriuretic Factor. J Am Heart Assoc 2020, 9 (10), e015110. - PMC - PubMed
1. Lv H; Wu H; Yin J; Qian J; Ge J Parity and Cardiovascular Disease Mortality: a Dose-Response Meta-Analysis of Cohort Studies. Sci Rep 2015, 5, 13411. - PMC - PubMed
1. Shawky NM; Patil CN; Dalmasso C; Maranon RO; Romero DG; Drummond H; Reckelhoff JF Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension. Hypertension 2020, 76 (3), 943–952. - PMC - PubMed
1. Rossi GP; Caroccia B; Seccia TM Role of estrogen receptors in modulating aldosterone biosynthesis and blood pressure. Steroids 2019, 152, 108486. - PubMed

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