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Review
. 2025 Apr 11;104(15):e41961.
doi: 10.1097/MD.0000000000041961.

Research hotspots and frontier analysis on Mendelian randomization in osteoporosis-related fields: A review based on bibliometric and visual analysis

Qingqing Zeng  1   2 , Sijie Gui  3 , Zhuolan Li  1 , Fei Wu  1 , Dan Peng  3 , Guqing Zeng  1
Affiliations
Review

Research hotspots and frontier analysis on Mendelian randomization in osteoporosis-related fields: A review based on bibliometric and visual analysis

Qingqing Zeng et al. Medicine (Baltimore). .

Abstract

This research seeks to thoroughly examine the present state and research hotspots in Mendelian randomization (MR) in osteoporosis (OP)-related fields, providing a reference for future research directions in this area. Following an exhaustive search of the Web of Science Core Collection database, our analysis utilized citation statistics for osteoporosis studies conducted from January 1, 2007, through March 15, 2024. Bibliometric and visual analyses were conducted using two online analysis systems, CiteSpace and VOSviewer. The analysis included a variety of dimensions, including the distribution of citations, authorship, published journals, year of publication, countries, co-occurrence keywords and keyword clustering. From 2007 to 2024, the number of publications in MR in OP-related fields showed an overall increased. High-impact publications and leading contributors were primarily from China, followed by the USA and England. The journal with the largest number of publications in MR in OP-related fields is the Journal of Bone and Mineral Research. Risk factor research, genome-wide associations, meta-analysis, fractures, and gene loci were the main research hotspots. Interdisciplinary integration, MR research combined with data from clinical trials and observational studies, represents the future development trend. Research on MR in OP-related fields has mainly been conducted in China, the USA, and England. The research hotspots were aimed at exploring the causative between risk factors and OP. Future studies are likely to center on multidisciplinary integration.

Keywords: bibliometric; hotspots; mendelian randomization; osteoporosis; visual analysis.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Trends in the volume of MR in OP-related fields articles from 2007 to 2024. MR = mendelian randomization, OP = osteoporosis.
Figure 2.
Figure 2.
The number of articles on MR in OP-related fields publications by countries from 2007 to 2024. MR = mendelian randomization, OP = osteoporosis.
Figure 3.
Figure 3.
National collaborative network mapping of MR in OP-related fields publications from 2007 to 2024. MR = mendelian randomization, OP = osteoporosis.
Figure 4.
Figure 4.
(A) keyword co-occurrence network map. (B) Authors keywords network map. (C) Density map of keyword-plus. MR = mendelian randomization, OP = osteoporosis.
Figure 5.
Figure 5.
The keyword frequency of MR in OP-related fields articles from 2007 to 2024. MR = mendelian randomization, OP = osteoporosis.
Figure 6.
Figure 6.
Keyword clustering network mapping of MR in OP-related fields articles from 2007 to 2024. MR = mendelian randomization, OP = osteoporosis.
Figure 7.
Figure 7.
The keyword clustering timeline graph of MR in OP-related fields articles from 2007 to 2024. MR = mendelian randomization, OP = osteoporosis.
See this image and copyright information in PMC

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