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. 2025 Mar 28;112(4):znaf061.
doi: 10.1093/bjs/znaf061.

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database

Prospective Lynch Syndrome Database
Collaborators

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database

Prospective Lynch Syndrome Database. Br J Surg. .

Abstract

This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.

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Figures

Fig. 1
Fig. 1
Cumulative incidence of a first CRC for path_MMR carriers with no previous CRC and cumulative incidence of metachronous CRC for path_MMR carriers with previously diagnosed CRC by gene (with 95% confidence intervals) a  MLH1. b  MSH2. c  MSH6. CRC, colorectal cancer; path_MMR, pathogenic MMR variant.
Fig. 2
Fig. 2
Cumulative incidence of metachronous CRC for path_MMR carriers who previously underwent segmental or extended resection by gene (with 95% confidence intervals) a All genes. b  MLH1. c  MSH2. d  MSH6. CRC, colorectal cancer; path_MMR, pathogenic MMR variant.
Fig. 3
Fig. 3
Overall survival of path_MMR carriers for segmental resection and extended colectomy groups a With prior or prevalent CRC. b With prospectively diagnosed CRC. CRC, colorectal cancer; path_MMR, pathogenic MMR variant.
See this image and copyright information in PMC

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