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Review
. 2025 Jun;42(6):2587-2605.
doi: 10.1007/s12325-025-03192-w. Epub 2025 Apr 15.

Lidocaine-A Promising Candidate for the Treatment of Cancer-Induced Bone Pain: A Narrative Review

Lihan Luo  1 , Yuqi Cheng  1 , Hanxi Wang  1 , Li Li  1 , Hanyun Niu  1 , Yuzhu Yang  1 , Qianqian Zhou  1 , Jiannan He  2 , Jianhong Xu  3
Affiliations
Review

Lidocaine-A Promising Candidate for the Treatment of Cancer-Induced Bone Pain: A Narrative Review

Lihan Luo et al. Adv Ther. 2025 Jun.

Abstract

Pain is one of the most common symptoms in patients with cancer, with cancer-induced bone pain (CIBP) significantly affecting their quality of life. Opioids are commonly used as first-line treatments for cancer pain, but their use requires caution due to non-mechanistic analgesia and significant side effects. As a result, there is a need for new non-opioid drugs that target cancer pain through specific mechanisms. Recent studies on the anticancer effects of lidocaine have highlighted its potential benefits in both treating cancer and alleviating cancer-induced pain. This article discusses the mechanism of action and clinical applications of lidocaine in cancer pain management, and suggests new treatment approaches for patients with CIBP.

Keywords: Cancer-induced bone pain; Lidocaine; Pain management.

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Conflict of interest statement

Declarations. Conflict of Interest: Lihan Luo, Yuqi Cheng, Hanxi Wang, Li Li, Hanyun Niu, Yuzhu Yang, Qianqian Zhou, Jiannan He, and Jianhong Xu have nothing to disclose. Ethical Approval: This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.

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