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. 2025 Jun 19;145(25):3056-3059.
doi: 10.1182/blood.2024027563.

Maternal Tmprss6 is required for hepcidin suppression and fetal health

Katherine L Fielding  1   2   3 , Cavan Bennett  1   2 , Anne Pettikiriarachchi  1 , Naomi Jones  1 , Rebecca Harding  1 , Alistair R D McLean  1 , Louise Randall  1 , Ute Schaeper  4 , Alberto Martinez  5 , Ricardo Ataíde  1   6 , Sant-Rayn Pasricha  1   2   3   7
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Free article

Maternal Tmprss6 is required for hepcidin suppression and fetal health

Katherine L Fielding et al. Blood. .
Free article

Abstract

The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.

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