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. 2025 Mar 28;112(4):znaf072.
doi: 10.1093/bjs/znaf072.

Molecular prognostic factors for liver transplantation of unresectable metastatic colorectal cancer

Seyed H Moosavi  1 , Kushtrim Kryeziu  1 , Ina A Eilertsen  1 , Luís Nunes  1 , Merete Hektoen  1 , Barbara Niederdorfer  1 , Henrik M Reims  2 , Trygve Syversveen  3 , Harald Grut  4 , Svein Dueland  5 , Pål-Dag Line  5   6 , Ragnhild A Lothe  1   6 , Anita Sveen  1   6
Affiliations

Molecular prognostic factors for liver transplantation of unresectable metastatic colorectal cancer

Seyed H Moosavi et al. Br J Surg. .
No abstract available

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Figures

Fig. 1
Fig. 1
Molecular characteristics of patients treated by LT for metastatic CRC a Oncoplot of somatic mutations for each gene in rows (14 genes; ordered according to mutation frequency) and each patient in the LT cohort in columns (34 patients; ordered according to the number of mutated genes). The mutation type is indicated by colour keys. Bar plots summarize the number of mutations per patient (top) and gene (right). Cells split by diagonal lines in the oncoplot and coloured black in the bar plots indicate genes and tumours with two mutations (counted once per tumour). Selected clinicopathological characteristics are indicated in the panels below. b Kaplan–Meier plot of overall survival according to RAS/TP53 co-mutations in patients treated by LT (34 patients). c Volcano plot of differentially expressed genes between liver metastases in the LT cohort (34 patients) and in the resection cohort (98 patients). The top 20 up-regulated genes in each group are indicated by gene symbols (ranked by log2 fold change and P value corrected for the FDR, plotted on log10 scale). The coloured dots indicate genes included in the top three enriched pathways from over-representation analysis of the REACTOME database, as specified (ranked by statistical significance). Black outlines indicate genes included in more than one of the pathways. d Bar plot of the five most significantly enriched signatures in the LT cohort (34 patients) and in the resection cohort (98 patients) from gene set enrichment analysis of a custom gene set collection (260 gene sets; Table S10). P values are FDR-corrected and plotted on log10 scale. SNV, single nucleotide variant; indel, insertion and deletion; MTV, metabolic tumour volume on PET; FDR, false discovery rate; LT, liver transplantation; CRC, colorectal cancer.
See this image and copyright information in PMC

References

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