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Case Reports
. 2025 Mar 16;17(3):e80649.
doi: 10.7759/cureus.80649. eCollection 2025 Mar.

Histamine Intolerance: An Overlooked Diagnosis of Recurrent Anaphylaxis-Like Symptoms

Takashi Nakamura  1 , Hirohisa Fujikawa  1   2 , Hirotake Ikeda  1 , Satoshi Mizuma  1
Affiliations
Case Reports

Histamine Intolerance: An Overlooked Diagnosis of Recurrent Anaphylaxis-Like Symptoms

Takashi Nakamura et al. Cureus. .

Abstract

Histamine intolerance is a common disorder associated with an impaired histamine metabolism. It should be considered in individuals with sporadic or repeated anaphylaxis-like symptoms after seafood consumption. We encountered a 26-year-old male patient who experienced recurrent episodes of anaphylaxis-like symptoms after ingesting seafood. A detailed history-taking and a histamine 50-skin-prick test confirmed the diagnosis of histamine intolerance. In addition, a low-histamine diet and prophylactic antihistamine medication did not result in symptom recurrence. Proper management of histamine intolerance can improve the individual's quality of life.

Keywords: allergy and anaphylaxis; fish allergy; food intolerance; food-induced anaphylaxis; histamine fish poisoning; histamine intolerance; histamine receptors; scombroid fish poisoning.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Changes in the size of wheals in the histamine 50-skin-prick test.
See this image and copyright information in PMC

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