Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Apr 2;16(4):540-541.
doi: 10.1021/acsmedchemlett.5c00142. eCollection 2025 Apr 10.

Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer

Ram W Sabnis  1
Affiliations
Editorial

Novel Piperidinylpyridinylcarbonitrile Derivatives as QPCT and QPCTL Inhibitors for Treating Cancer

Ram W Sabnis. ACS Med Chem Lett. .

Abstract

Provided herein are novel piperidinylpyridinylcarbonitrile derivatives as QPCT and QPCTL inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds.

PubMed Disclaimer

Conflict of interest statement

The author declares no competing financial interest.

References

    1. Yu L.; Sun Y.; Xie L.; Tan X.; Wang P.; Xu S. Targeting QPCTL: An emerging therapeutic opportunity. J. Med. Chem. 2025, 68, 929–943. 10.1021/acs.jmedchem.4c02247. - DOI - PubMed
    1. Oghenemaro E. F.; Uthirapathy S.; Nathiya D.; Kaur P.; Kumar M. R.; Verma A. Role of glutaminyl-peptide cyclotransferase-like protein (QPCTL) in cancer: From molecular mechanics to immunotherapy. Gene 2025, 937, 149153.10.1016/j.gene.2024.149153. - DOI - PubMed
    1. Guan F.; Wang R.; Yi Z.; Luo P.; Liu W.; Xie Y.; Liu Z.; Xia Z.; Zhang H.; Cheng Q. Tissue macrophages: Origin, heterogeneity, biological functions, diseases and therapeutic targets. Sig. Transduct. Target. Ther. 2025, 10, 93.10.1038/s41392-025-02124-y. - DOI - PMC - PubMed
    1. Mempel T. R.; Lill J. K.; Altenburger L. M. How chemokines organize the tumour microenvironment. Nat. Rev. Cancer 2024, 24, 28–50. 10.1038/s41568-023-00635-w. - DOI - PMC - PubMed
    1. Sabnis R. W. Novel phenylpiperidine derivatives as QPCT and QPCTL inhibitors for treating cancer or fibrotic diseases. ACS Med. Chem. Lett. 2024, 15, 1826–1827. 10.1021/acsmedchemlett.4c00495. - DOI - PMC - PubMed

Publication types

LinkOut - more resources