Mirikizumab for Ulcerative Colitis: A Game-Changer or Just Another Incremental Advance?
- PMID: 40237908
- DOI: 10.1007/s10620-025-09047-2
Mirikizumab for Ulcerative Colitis: A Game-Changer or Just Another Incremental Advance?
Keywords: Interleukins; Random clinical trials; Therapeutic monoclonal antibodies; Ulcerative colitis.
Conflict of interest statement
Declarations. Conflict of interest: The authors declare no competing interests.
Similar articles
-
Efficacy and safety of mirikizumab compared with currently approved biologic drugs for the treatment of ulcerative colitis: A systematic review and network meta-analysis.Pharmacotherapy. 2024 Oct;44(10):811-821. doi: 10.1002/phar.4611. Epub 2024 Sep 25. Pharmacotherapy. 2024. PMID: 39320112
-
Two-Year Efficacy and Safety of Mirikizumab Following 104 Weeks of Continuous Treatment for Ulcerative Colitis: Results From the LUCENT-3 Open-Label Extension Study.Inflamm Bowel Dis. 2024 Dec 5;30(12):2245-2258. doi: 10.1093/ibd/izae024. Inflamm Bowel Dis. 2024. PMID: 38459910 Free PMC article. Clinical Trial.
-
Mirikizumab Pharmacokinetics in Patients with Moderately to Severely Active Ulcerative Colitis: Results from Phase III LUCENT Studies.Clin Pharmacokinet. 2023 Oct;62(10):1479-1491. doi: 10.1007/s40262-023-01281-z. Epub 2023 Aug 23. Clin Pharmacokinet. 2023. PMID: 37610533 Free PMC article.
-
Mirikizumab: A New Therapeutic Option for the Treatment of Ulcerative Colitis.Ann Pharmacother. 2024 Nov;58(11):1134-1139. doi: 10.1177/10600280241229742. Epub 2024 Feb 12. Ann Pharmacother. 2024. PMID: 38344998 Review.
-
Efficacy and safety of Mirikizumab for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials.BMC Gastroenterol. 2025 Apr 29;25(1):307. doi: 10.1186/s12876-025-03627-2. BMC Gastroenterol. 2025. PMID: 40301737 Free PMC article.
References
-
- Dubinsky MC, Panaccione R, Lewis JD, et al. Impact of bowel urgency on quality of life and clinical outcomes in patients with ulcerative colitis. Crohn's & Colitis 360 2022; 4:otac016.
-
- Dubinsky MC, Clemow DB, Hunter Gibble T et al. Clinical effect of mirikizumab treatment on bowel urgency in patients with moderately to severely active ulcerative colitis and the clinical relevance of bowel urgency improvement for disease remission. Crohns Colitis 2023;5:otac44.
-
- St-Pierre J, Choi D, Fear E et al. Mirikizumab in the treatment of ulcerative colitis: initial real-world data in a population from a large tertiary center. Dig Dis Sci 2025. https://doi.org/10.1007/s10620-025-08950-y - DOI - PubMed
Publication types
LinkOut - more resources
Full Text Sources