Mirikizumab for Ulcerative Colitis: A Game-Changer or Just Another Incremental Advance?

Affiliations

¹ Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA.
² Department of Internal Medicine, MedStar Health, Baltimore, MD, USA.
³ Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. dahhamalsoud@gmail.com.

Editorial

Bisher Sawaf et al. Dig Dis Sci. 2025 Jun.

. 2025 Jun;70(6):1946-1947.

doi: 10.1007/s10620-025-09047-2. Epub 2025 Apr 16.

¹ Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA.
² Department of Internal Medicine, MedStar Health, Baltimore, MD, USA.
³ Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. dahhamalsoud@gmail.com.

No abstract available

Keywords: Interleukins; Random clinical trials; Therapeutic monoclonal antibodies; Ulcerative colitis.

Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

1. Raine T, Danese S. Breaking through the therapeutic ceiling: what will it take? Gastroenterology 2022;162:1507–1511. - DOI - PubMed
1. Dubinsky MC, Panaccione R, Lewis JD, et al. Impact of bowel urgency on quality of life and clinical outcomes in patients with ulcerative colitis. Crohn's & Colitis 360 2022; 4:otac016.
1. D’Haens G, Dubinsky M, Kobayashi T et al. Mirikizumab as Induction and maintenance therapy for ulcerative colitis. N Engl J Med 2023;388:2444–2455. - DOI - PubMed
1. Dubinsky MC, Clemow DB, Hunter Gibble T et al. Clinical effect of mirikizumab treatment on bowel urgency in patients with moderately to severely active ulcerative colitis and the clinical relevance of bowel urgency improvement for disease remission. Crohns Colitis 2023;5:otac44.
1. St-Pierre J, Choi D, Fear E et al. Mirikizumab in the treatment of ulcerative colitis: initial real-world data in a population from a large tertiary center. Dig Dis Sci 2025. https://doi.org/10.1007/s10620-025-08950-y - DOI - PubMed