Bovine H5N1 binds poorly to human-type sialic acid receptors

Jefferson J S Santos^#¹, Shengyang Wang^#², Ryan McBride^#², Lorin Adams^#^{3

4}, Ruth Harvey³, Yan Zhao¹, Antoni G Wrobel⁵, Steven Gamblin⁵, John Skehel⁵, Nicola S Lewis^{6

7}, James C Paulson⁸, Scott E Hensley⁹

Affiliations

¹ Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Department of Molecular Medicine and Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.
³ Worldwide Influenza Centre, The Francis Crick Institute, London, UK.
⁴ Royal Veterinary College, University of London, London, UK.
⁵ Structural Biology of Disease Processes Lab, Francis Crick Institute, London, UK.
⁶ Worldwide Influenza Centre, The Francis Crick Institute, London, UK. nicola.lewis@crick.ac.uk.
⁷ Royal Veterinary College, University of London, London, UK. nicola.lewis@crick.ac.uk.
⁸ Department of Molecular Medicine and Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA. jpaulson@scripps.edu.
⁹ Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. hensley@pennmedicine.upenn.edu.

^# Contributed equally.

PMID: 40240859
DOI: 10.1038/s41586-025-08821-6

Comment

Bovine H5N1 binds poorly to human-type sialic acid receptors

Jefferson J S Santos et al. Nature. 2025 Apr.

. 2025 Apr;640(8059):E18-E20.

doi: 10.1038/s41586-025-08821-6. Epub 2025 Apr 16.

Authors

Affiliations

¹ Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Department of Molecular Medicine and Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.
³ Worldwide Influenza Centre, The Francis Crick Institute, London, UK.
⁴ Royal Veterinary College, University of London, London, UK.
⁵ Structural Biology of Disease Processes Lab, Francis Crick Institute, London, UK.
⁶ Worldwide Influenza Centre, The Francis Crick Institute, London, UK. nicola.lewis@crick.ac.uk.
⁷ Royal Veterinary College, University of London, London, UK. nicola.lewis@crick.ac.uk.
⁸ Department of Molecular Medicine and Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA. jpaulson@scripps.edu.
⁹ Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. hensley@pennmedicine.upenn.edu.

^# Contributed equally.

PMID: 40240859
DOI: 10.1038/s41586-025-08821-6

No abstract available

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Conflict of interest statement

Competing interests: S.E.H. reports receiving consulting fees from Sanofi, Pfizer, Lumen, Novavax and Merck. The authors declare no other competing interests.

Update of

Bovine H5N1 influenza virus binds poorly to human-type sialic acid receptors.
Santos JJS, Wang S, McBride R, Zhao Y, Paulson JC, Hensley SE. Santos JJS, et al. bioRxiv [Preprint]. 2024 Aug 2:2024.08.01.606177. doi: 10.1101/2024.08.01.606177. bioRxiv. 2024. Update in: Nature. 2025 Apr;640(8059):E18-E20. doi: 10.1038/s41586-025-08821-6. PMID: 39131285 Free PMC article. Updated. Preprint.

Comment on

Pathogenicity and transmissibility of bovine H5N1 influenza virus.
Eisfeld AJ, Biswas A, Guan L, Gu C, Maemura T, Trifkovic S, Wang T, Babujee L, Dahn R, Halfmann PJ, Barnhardt T, Neumann G, Suzuki Y, Thompson A, Swinford AK, Dimitrov KM, Poulsen K, Kawaoka Y. Eisfeld AJ, et al. Nature. 2024 Sep;633(8029):426-432. doi: 10.1038/s41586-024-07766-6. Epub 2024 Jul 8. Nature. 2024. PMID: 38977017 Free PMC article.

References

1. Nguyen, T. Q. et al. Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle. Preprint at bioRxiv https://doi.org/10.1101/2024.05.01.591751 (2024).
1. Burrough, E. R. et al. Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus infection in domestic dairy cattle and cats, United States, 2024. Emerg. Infect. Dis. 30, 1335–1343 (2024). - DOI - PubMed - PMC
1. Eisfeld, A. J. et al. Pathogenicity and transmissibility of bovine H5N1 influenza virus. Nature 633, 426–432 (2024). - DOI - PubMed - PMC
1. Thompson, A. J. & Paulson, J. C. Adaptation of influenza viruses to human airway receptors. J. Biol. Chem. 296, 100017 (2021). - DOI - PubMed
1. Nelli, R. K. et al. Sialic acid receptor specificity in mammary gland of dairy cattle infected with highly pathogenic avian influenza A (H5N1) virus. Emerg. Infect. Dis. 30, 1361–1373 (2024). - DOI - PubMed - PMC

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Bovine H5N1 binds poorly to human-type sialic acid receptors

Affiliations

Bovine H5N1 binds poorly to human-type sialic acid receptors

Authors

Affiliations

Conflict of interest statement

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Comment on

References

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