Receptor-binding specificity of a bovine influenza A virus

Pradeep Chopra^#^{1

2}, Sean D Ray^#^{2

3

4}, Caroline K Page^{2

3

4}, Justin D Shepard^{2

3

4}, Ahmed Kandeil^{5

6}, Trushar Jeevan^{5

6}, Andrew S Bowman^{6

7}, Ali H Ellebedy^{8

9

10}, Richard J Webby^{5

6}, Robert P de Vries¹¹, S Mark Tompkins^{12

13

14}, Geert-Jan Boons^{15

16

17

18}

Affiliations

¹ Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
² Center for Influenza Disease and Emergence Response (CIDER), University of Georgia, Athens, GA, USA.
³ Department of Infectious Diseases, University of Georgia, Athens, GA, USA.
⁴ Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA.
⁵ Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
⁶ St Jude Center of Excellence for Influenza Research and Response, Memphis, TN, USA.
⁷ Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
⁸ Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
⁹ Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA.
¹⁰ The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.
¹¹ Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
¹² Center for Influenza Disease and Emergence Response (CIDER), University of Georgia, Athens, GA, USA. smt@uga.edu.
¹³ Department of Infectious Diseases, University of Georgia, Athens, GA, USA. smt@uga.edu.
¹⁴ Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA. smt@uga.edu.
¹⁵ Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA. gjboons@ccrc.uga.edu.
¹⁶ Center for Influenza Disease and Emergence Response (CIDER), University of Georgia, Athens, GA, USA. gjboons@ccrc.uga.edu.
¹⁷ Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. gjboons@ccrc.uga.edu.
¹⁸ Department of Chemistry, University of Georgia, Athens, GA, USA. gjboons@ccrc.uga.edu.

^# Contributed equally.

PMID: 40240861
DOI: 10.1038/s41586-025-08822-5

Comment

Receptor-binding specificity of a bovine influenza A virus

Pradeep Chopra et al. Nature. 2025 Apr.

. 2025 Apr;640(8059):E21-E27.

doi: 10.1038/s41586-025-08822-5. Epub 2025 Apr 16.

Authors

Affiliations

¹ Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
² Center for Influenza Disease and Emergence Response (CIDER), University of Georgia, Athens, GA, USA.
³ Department of Infectious Diseases, University of Georgia, Athens, GA, USA.
⁴ Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA.
⁵ Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
⁶ St Jude Center of Excellence for Influenza Research and Response, Memphis, TN, USA.
⁷ Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
⁸ Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
⁹ Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA.
¹⁰ The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.
¹¹ Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
¹² Center for Influenza Disease and Emergence Response (CIDER), University of Georgia, Athens, GA, USA. smt@uga.edu.
¹³ Department of Infectious Diseases, University of Georgia, Athens, GA, USA. smt@uga.edu.
¹⁴ Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA. smt@uga.edu.
¹⁵ Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA. gjboons@ccrc.uga.edu.
¹⁶ Center for Influenza Disease and Emergence Response (CIDER), University of Georgia, Athens, GA, USA. gjboons@ccrc.uga.edu.
¹⁷ Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. gjboons@ccrc.uga.edu.
¹⁸ Department of Chemistry, University of Georgia, Athens, GA, USA. gjboons@ccrc.uga.edu.

^# Contributed equally.

PMID: 40240861
DOI: 10.1038/s41586-025-08822-5

No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare no competing interests.

Update of

Receptor Binding Specificity of a Bovine A(H5N1) Influenza Virus.
Chopra P, Page CK, Shepard JD, Ray SD, Kandeil A, Jeevan T, Bowman AS, Ellebedy AH, Webby RJ, de Vries RP, Tompkins SM, Boons GJ. Chopra P, et al. bioRxiv [Preprint]. 2024 Jul 31:2024.07.30.605893. doi: 10.1101/2024.07.30.605893. bioRxiv. 2024. Update in: Nature. 2025 Apr;640(8059):E21-E27. doi: 10.1038/s41586-025-08822-5. PMID: 39131339 Free PMC article. Updated. Preprint.

Comment on

Pathogenicity and transmissibility of bovine H5N1 influenza virus.
Eisfeld AJ, Biswas A, Guan L, Gu C, Maemura T, Trifkovic S, Wang T, Babujee L, Dahn R, Halfmann PJ, Barnhardt T, Neumann G, Suzuki Y, Thompson A, Swinford AK, Dimitrov KM, Poulsen K, Kawaoka Y. Eisfeld AJ, et al. Nature. 2024 Sep;633(8029):426-432. doi: 10.1038/s41586-024-07766-6. Epub 2024 Jul 8. Nature. 2024. PMID: 38977017 Free PMC article.

References

1. Paulson, J. C. & de Vries, R. P. H5N1 receptor specificity as a factor in pandemic risk. Virus Res. 178, 99–113 (2013). - DOI - PubMed
1. de Graaf, M. & Fouchier, R. A. Role of receptor binding specificity in influenza A virus transmission and pathogenesis. EMBO J. 33, 823–841 (2014). - DOI - PubMed - PMC
1. Eisfeld, A. J. et al. Pathogenicity and transmissibility of bovine H5N1 influenza virus. Nature 633, 426–432 (2024). - DOI - PubMed - PMC
1. Ma, S. et al. Asymmetrical biantennary glycans prepared by a stop-and-go strategy reveal receptor binding evolution of human influenza A viruses. JACS Au 4, 607–618 (2024). - DOI - PubMed - PMC
1. Hiono, T. et al. Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X. Arch. Virol. 161, 307–316 (2016). - DOI - PubMed

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Receptor-binding specificity of a bovine influenza A virus

Affiliations

Receptor-binding specificity of a bovine influenza A virus

Authors

Affiliations

Conflict of interest statement

Update of

Comment on

References

Publication types

LinkOut - more resources

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