Stroke Outcomes in a Population-Focused Urban Hypertension Program in Brazil and Senegal

Abstract

Background: Stroke is one of the major causes of death worldwide, mainly in low- and middle-income countries. The implementation of multifaceted strategies aiming at blood pressure control may change the global burden of stroke.

Methods and results: We evaluated the impact of a multisector urban cardiovascular health initiative (CARDIO4Cities) on stroke outcomes in Dakar, Senegal, and São Paulo, Brazil. Data covered preintervention, intervention, and follow-up periods with ongoing intervention from 2016 to 2021. An interrupted time series analysis and a segmented regression approach were used to evaluate temporal trends. The relative risk of stroke hospitalization was analyzed with a generalized linear model. In São Paulo, data could also be compared between intervention and control districts. A total of 3445 stroke hospitalizations were analyzed in Dakar and 4491 in São Paulo. In both cities, age-standardized stroke hospitalization rates (Dakar: -26%; São Paulo: -54% on average across 2 districts) and the risk of death from stroke declined over the intervention period. In São Paulo, the baseline risk of stroke hospitalization was comparable across the city. In the follow-up period, the risk was 24.5% lower in the intervention districts compared with the rest of the city (P<0.05). The COVID-19 situation did not change this dynamic.

Conclusion: The implementation of the multisectoral CARDIO4Cities initiative correlated with positive trends in stroke outcomes. Interventions to reduce cardiovascular risk and improve hypertension management at population level appear to rapidly translate into reduced stroke-related hospitalizations and mortality.

Keywords: cardiovascular disease; cardiovascular risk; hypertension; population health; stroke; urban.