Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 16;25(1):714.
doi: 10.1186/s12885-025-14132-w.

The role of CDK8 gene polymorphisms in bladder cancer susceptibility and prognosis: a study in the Chinese Han population

Zhilong Li #  1 , Min Su #  1 , Qin Li  1 , Xuelian Zheng  1 , Yaping Song  1 , Yanyun Wang  1 , Bin Zhou  2 , Lin Zhang  3
Affiliations

The role of CDK8 gene polymorphisms in bladder cancer susceptibility and prognosis: a study in the Chinese Han population

Zhilong Li et al. BMC Cancer. .

Abstract

Background: Cyclin-dependent kinase 8 (CDK8) has been implicated in various tumors, with its role differing across tumor types. However, the association between CDK8 polymorphisms and bladder cancer (BC) remains unclear. This study investigated the association between CDK8 polymorphisms and BC susceptibility and prognosis.

Methods: This case-control study included 271 patients with BC and 381 healthy controls. Two-tag single-nucleotide polymorphisms in the CDK8 gene (rs17083838 and rs7992670) were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Statistical analyses were performed using SNPstats and SPSS software to assess genetic associations.

Results: The AG/AA genotypes of rs17083838 were associated with a significantly reduced risk of BC under the dominant model (P < 0.001, odds ratio [95% confidence interval] = 0.50 [0.33-0.76]). Stratified analysis revealed that the AG genotype of rs17083838 increased the risk of postoperative recurrence in patients with stage IV BC (P = 0.007). For rs7992670, females with the AG/AA genotype exhibited a 2.07-fold higher risk of BC than males, whereas smokers with the same genotype showed a 2.13-fold higher risk than non-smokers. The GG genotype of rs7992670 was associated with better overall survival in patients with stage III BC (P = 0.023). Among patients with recurrent muscle-invasive BC, those with the GG/AA genotype showed significantly improved survival compared with those carrying the AG genotype (P = 0.023).

Conclusions: CDK8 polymorphisms influence BC susceptibility and prognosis, with rs17083838 showing a protective effect and rs7992670 being associated with increased risk and survival outcomes in specific subgroups.

Impact: This study highlights the potential of CDK8 polymorphisms as biomarkers for BC susceptibility and prognosis, emphasizing the need for further research.

Keywords: CDK8; Bladder cancer; Genetic susceptibility; PCR-RFLP; SNP polymorphism.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethical approval: This study was approved by the Ethics Committee of West China Second University Hospital and West China Hospital, Sichuan University (Institutional Review Board Approval Number: Medical Research Project Approval No. 017, 2012). This study adhered to the ethical principles of the Helsinki Declaration of the World Medical Association. Consent to participate: Written informed consent was obtained from all sample donors. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Genotypes of CDK8 rs17083838 and rs7992670 on the 6% polyacrylamide gels. (A) Genotypes of rs17083838. M: marker; Line 1 and 4: GG genotype. Line 2 and 5: AA genotype. Line 3 and 6: AG genotype. (B) Genotypes of rs7992670. M: marker; Line 1 and 4: GG genotype. Line 2 and 5: AG genotype. Line 3 and 6: AA genotype
Fig. 2
Fig. 2
The association between rs17083838 polymorphism and postoperative recurrence risk in stage IV patients. A, codominant model; B, over-dominant model
Fig. 3
Fig. 3
The association between rs7992670 polymorphism and overall survival in stage III patients. A, recessive model; B, dominant model; C, codominant model
Fig. 4
Fig. 4
Association of rs7992670 polymorphism with overall survival in relapsed MIBC patients
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63. - PubMed
    1. Weber A, Vignat J, Shah R, Morgan E, Laversanne M, Nagy P, Kenessey I, Znaor A. Global burden of bladder cancer mortality in 2020 and 2040 according to GLOBOCAN estimates. World J Urol. 2024;42(1):237. - PMC - PubMed
    1. Richters A, Aben KKH, Kiemeney L. The global burden of urinary bladder cancer: an update. World J Urol. 2020;38(8):1895–904. - PMC - PubMed
    1. Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Clark PE, Downs TM, Efstathiou JA, Flaig TW, Friedlander T, Greenberg RE, Guru KA, Hahn N, Herr HW, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Meeks JJ, Michalski J, Montgomery JS, Pagliaro LC, Pal SK, Patterson A, Plimack ER, Pohar KS, Porter MP, Preston MA, Sexton WJ, Siefker-Radtke AO, Sonpavde G, Tward J, Wile G, Dwyer MA, Gurski LA. Bladder cancer, version 5.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2017;15(10):1240–67. - PubMed
    1. Zhang W, Zhang J, Zhang Z, Guo Y, Wu Y, Wang R, Wang L, Mao S, Yao X. Overexpression of indoleamine 2,3-Dioxygenase 1 promotes Epithelial-Mesenchymal transition by activation of the IL-6/STAT3/PD-L1 pathway in bladder Cancer. Transl Oncol. 2019;12(3):485–92. - PMC - PubMed

Substances

Supplementary concepts

LinkOut - more resources