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. 2025 Apr 2:12:1514504.
doi: 10.3389/fmed.2025.1514504. eCollection 2025.

Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China

Zhenglong Guo  1 , Wenke Yang  1 , Qiongrui Zhao  1 , Yuwei Zhang  1 , Xin Wang  1 , Jinming Wang  1 , Ruili Wang  1   2 , Bingtao Hao  1 , Shixiu Liao  1
Affiliations

Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China

Zhenglong Guo et al. Front Med (Lausanne). .

Erratum in

Abstract

Background and objective: Increased nuchal translucency (NT) thickness measured at 11-14 weeks of gestation in fetuses has been linked to adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in fetuses with NT ≥3.0 mm.

Methods: This retrospective analysis included 4,200 singleton pregnancies diagnosed with increased NT thickness (≥3.0 mm) through first-trimester ultrasound screening across 76 hospitals in Henan Province from 2017 to 2021. Follow-up on pregnancy outcomes was completed through telephone interviews and electronic medical records.

Results: Among the 4,200 pregnancies with NT ≥3.0 mm, adverse pregnancy outcomes were observed in 31.5% of the fetuses. These outcomes included elective termination of pregnancy (TOP), spontaneous abortion (SA), threatened abortion (TA), and live birth with malformations. A total of 547 fetuses underwent further examination through karyotype analysis after genetic counseling, revealing that 10.2% were aneuploid, primarily due to Trisomy 21 (7.1%).

Conclusion: The incidence of increased NT in our study was 0.49%, which was associated with chromosomal abnormalities and developmental disorders, leading to an increased risk of adverse pregnancy outcomes. Abnormal ultrasound soft markers, along with NT > 4 mm, may further elevate the risk of adverse pregnancy outcomes. These findings should be taken seriously in the context of further prenatal diagnosis for fetuses with increased NT.

Keywords: chromosome abnormalities; first-trimester screening; nuchal translucency thickness; pregnancy outcome; ultrasound soft indicators.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Giorlandino C, Cignini P, Padula F, Giannarelli D, d’Emidio L, Aloisi A, et al. . Effects of exogenous progesterone on fetal nuchal translucency: an observational prospective study. Am J Obstet Gynecol. (2015) 212:335.e1. doi: 10.1016/j.ajog.2014.10.003, PMID: - DOI - PubMed
    1. Nicolaides KH, Azar G, Byrne D, Mansur C, Marks K. Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy. BMJ. (1992) 304:867–9. doi: 10.1136/bmj.304.6831.867, PMID: - DOI - PMC - PubMed
    1. Wagner P, Sonek J, Hoopmann M, Abele H, Kagan KO. First-trimester screening for trisomies 18 and 13, triploidy and turner syndrome by detailed early anomaly scan. Ultrasound Obstet Gynecol. (2016) 48:446–51. doi: 10.1002/uog.15829, PMID: - DOI - PubMed
    1. Sepulveda W, Wong AE, Casasbuenas A. Nuchal translucency and nasal bone in first-trimester ultrasound screening for aneuploidy in multiple pregnancies. Ultrasound Obstet Gynecol. (2009) 33:152–6. doi: 10.1002/uog.6222, PMID: - DOI - PubMed
    1. Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH. Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus. Ultrasound Obstet Gynecol. (2020) 55:637–44. doi: 10.1002/uog.21956, PMID: - DOI - PubMed

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