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Editorial

. 2025 Mar 25;9(2):rkaf038.

doi: 10.1093/rap/rkaf038. eCollection 2025.

Ustekinumab merits further exploration in Takayasu arteritis despite a failed randomized controlled trial

Durga Prasanna Misra¹

Affiliations

PMID: 40241922
PMCID: PMC12000531
DOI: 10.1093/rap/rkaf038

Editorial

Ustekinumab merits further exploration in Takayasu arteritis despite a failed randomized controlled trial

Durga Prasanna Misra. Rheumatol Adv Pract. 2025.

. 2025 Mar 25;9(2):rkaf038.

doi: 10.1093/rap/rkaf038. eCollection 2025.

Author

Durga Prasanna Misra¹

Affiliation

¹ Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.

PMID: 40241922
PMCID: PMC12000531
DOI: 10.1093/rap/rkaf038

No abstract available

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Figures

Figure 1. — Figure 1.
Rationale for the potential utility of ustekinumab in Takayasu arteritis. Created in https://BioRender.com/e12d914

See this image and copyright information in PMC

Comment in

doi: 10.1093/rap/rkaf013

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References

1. Misra DP, Singh K, Rathore U et al. Management of Takayasu arteritis. Best Pract Res Clin Rheumatol 2023;37:101826. - PubMed
1. Jagtap S, Mishra P, Rathore U et al. Increased mortality rate in Takayasu arteritis is largely driven by cardiovascular disease—a cohort study. Rheumatology (Oxford) 2024;63:3337–45. - PubMed
1. Misra DP, Singh K, Sharma A, Agarwal V. Arterial wall fibrosis in Takayasu arteritis and its potential for therapeutic modulation. Front Immunol 2023;14:1174249. - PMC - PubMed
1. Yoshifuji H, Ishii T, Ohashi H et al. Phase 3, multicenter, randomized, double-blind, placebo- controlled, parallel-group study of ustekinumab in patients with Takayasu arteritis. Rheumatol Adv Pract 2025;rkaf013. 10.1093/rap/rkaf013 - DOI - PMC - PubMed
1. Saadoun D, Garrido M, Comarmond C et al. Th1 and th17 cytokines drive inflammation in takayasu arteritis. Arthritis Rheumatol 2015;67:1353–60. - PubMed

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