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. 2025 Mar 10;4(2):100452.
doi: 10.1016/j.jacig.2025.100452. eCollection 2025 May.

Correlation between total IgE level and asthma symptom severity in hospitalized children

Tasmia Rezwan  1 , Michelle Perez  2 , Sarah Jacobs  3 , Justina Shafik  3 , William B Mitchell  2 , Laura A Conrad  2 , Sara H Soshnick  2
Affiliations

Correlation between total IgE level and asthma symptom severity in hospitalized children

Tasmia Rezwan et al. J Allergy Clin Immunol Glob. .

Abstract

Background: Status asthmaticus is a common reason for hospitalization and pediatric intensive care unit (PICU) admission among children. While previous studies have demonstrated a correlation between elevated IgE levels and asthma severity in outpatient settings, studies analyzing IgE levels in an inpatient cohort are limited.

Objective: We examined the relationship between baseline IgE levels and symptom severity, maximum respiratory support, and PICU and hospital length of stay in an inpatient pediatric cohort.

Methods: This was a single-center retrospective chart review of children admitted to the Children's Hospital at Montefiore with status asthmaticus as their primary diagnosis. The primary goal was to determine the relationship between baseline IgE levels and severity of illness at time of admission. Secondary outcomes included maximum respiratory support, and PICU and hospital length of stay.

Results: We identified a statistically significant difference (P = .043) in baseline IgE levels between the PICU (median, 608 U/mL) and floor groups (405 IU/mL). There was a positive correlation between IgE level and PICU length of stay (P = .004).

Conclusion: Elevated baseline IgE level is correlated with higher asthma symptom severity when hospitalized and with longer PICU length of stay. Our study adds to the growing body of evidence that those with high baseline IgE levels are at risk of having severe asthma symptomology.

Keywords: IgE; Pediatric asthma; asthma exacerbation; immunoglobulins; immunology; pulmonology; status asthmaticus.

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Conflict of interest statement

Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.

Figures

Fig 1
Fig 1
Patient selection for chart review.
Fig 2
Fig 2
Comparison of baseline IgE levels in patients admitted to PICU versus floor. P value for Mann-Whitney U test shown. IQR, Interquartile range; SEM, standard error of mean.
Fig 3
Fig 3
Baseline IgE level across maximum required respiratory support. P value for Kruskal- Wallis test shown. ECMO, Extracorporeal membrane oxygenation; IQR, interquartile range; NC, nasal cannula; NIPPV, noninvasive PPV; RA, room air; SEM, standard error of mean.
Fig 4
Fig 4
Comparison of baseline IgE levels with and without positive pressure requirement. RA + NC + HFNC = no positive pressure; NIPPV + intubation = positive pressure. NC, Nasal cannula; NIPPV, noninvasive PPV; RA, room air.
Fig 5
Fig 5
Baseline IgE level versus PLOS. Spearman correlation r = 0.362; P = .004.
Fig 6
Fig 6
Baseline IgE level versus HLOS. Spearman correlation r = 0.035; P = .597.
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