Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun;51(6):1194-1195.
doi: 10.1007/s00134-025-07896-z. Epub 2025 Apr 17.

Selection bias in the "TRAIN" randomized clinical trial: implications for meta-analyses-Author's reply

Pierre-Louis Blot  1 , Maxime Renaux  1 , Timothée Ayasse  1 , Jean-Michel Constantin  1 , Rayan Braïk  2
Affiliations

Selection bias in the "TRAIN" randomized clinical trial: implications for meta-analyses-Author's reply

Pierre-Louis Blot et al. Intensive Care Med. 2025 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors declare that they have no conflicts of interest related to this manuscript.

References

    1. Blot P-L, Renaux M, Ayasse T et al (2025) Liberal vs. restrictive transfusion strategies for acute brain injury: a systematic review and frequentist-Bayesian meta-analysis. Intensive Care Med 51:353–363. https://doi.org/10.1007/s00134-025-07807-2 - DOI - PubMed
    1. Garg R (2025) Selection bias in the “TRAIN” randomized clinical trial: implications for meta-analyses. Intensive Care Med. https://doi.org/10.1007/s00134-025-07867-4 - DOI - PubMed
    1. Minozzi S, Dwan K, Borrelli F, Filippini G (2022) Reliability of the revised Cochrane risk-of-bias tool for randomised trials (RoB2) improved with the use of implementation instruction. J Clin Epidemiol 141:99–105. https://doi.org/10.1016/j.jclinepi.2021.09.021 - DOI - PubMed
    1. Yuan X, Zhang S, Wan J et al (2024) Efficacy of restrictive versus liberal transfusion strategies in patients with traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials. Ann Intensive Care 14:177. https://doi.org/10.1186/s13613-024-01411-1 - DOI - PubMed - PMC
    1. Larcipretti ALL, Udoma-Udofa OC, Gomes FC et al (2025) Transfusion practices in traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials. Crit Care Med. https://doi.org/10.1097/CCM.0000000000006585 - DOI - PubMed

LinkOut - more resources