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. 2025 Jun 1;11(6):666-668.
doi: 10.1001/jamaoncol.2025.0499.

Adoption of Broad Genomic Profiling in Patients With Cancer

Xiao Wang  1   2 , John Rothen  2 , Sida Huang  3 , Jessica B Long  2 , Pamela R Soulos  2 , Sarah B Goldberg  1 , Ronac Mamtani  4 , Carolyn J Presley  5 , Natalia Kunst  2   6 , Shuangge Ma  7 , Shi-Yi Wang  2   3 , Cary P Gross  2   3   8 , Michaela A Dinan  2   3
Affiliations

Adoption of Broad Genomic Profiling in Patients With Cancer

Xiao Wang et al. JAMA Oncol. .
No abstract available

Plain language summary

This cross-sectional study examines the use of broad genomic profiling in patients with metastatic cancer.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr X. Wang reported receiving grants from the National Cancer Institute during the conduct of the study. Dr Soulos reported receiving grants from the National Cancer Institute during the conduct of the study. Dr Goldberg reported receiving grants from AstraZeneca, Boehringer Ingelheim, and Mirati and personal fees from AstraZeneca, Daiichi Sankyo, Johnson & Johnson, Regeneron, Eli Lilly, Summit Therapeutics, and Bayer outside the submitted work. Dr Mamtani reported receiving grants from Merck and Astellas and personal fees from BMS, Roche, Merck, and Astellas outside the submitted work. Dr Gross reported receiving grants from Johnson & Johnson and the National Comprehensive Cancer Network outside the submitted work. Dr Dinan reported receiving grants from the National Institutes of Health during the conduct of the study. No other disclosures were reported.

References

    1. Chase M, Xu Y, Caplan EO, et al. CGE22-096: trends in the use of comprehensive genomic profiling among older patients with advanced cancer from 2018 to 2020 in the United States: findings from the SEQUENCE Study. J Nat Compr Cancer Netw. 2022;20(3.5). doi: 10.6004/jnccn.2021.7291 - DOI
    1. Markt SC, Booker BD, Bensken W, et al. Sociodemographic and clinical factors associated with receipt of biomarker testing in patients with metastatic colorectal cancer. Cancer Med. 2023;12(2):1850-1859. doi: 10.1002/cam4.4995 - DOI - PMC - PubMed
    1. Sheinson DM, Wong WB, Meyer CS, et al. Trends in use of next-generation sequencing in patients with solid tumors by race and ethnicity after implementation of the Medicare national coverage determination. JAMA Netw Open. 2021;4(12):e2138219. doi: 10.1001/jamanetworkopen.2021.38219 - DOI - PMC - PubMed
    1. Zhao Y, Dimou A, Fogarty ZC, et al. Real-world trends, rural-urban differences, and socioeconomic disparities in utilization of narrow versus broad next-generation sequencing panels. Cancer Res Commun. 2024;4(2):303-311. doi: 10.1158/2767-9764.CRC-23-0190 - DOI - PMC - PubMed
    1. Robert Graham Center, Policy Studies in Family Medicine & Primary Care . Social Deprivation Index (SDI). Accessed March 3, 2025. https://www.graham-center.org/maps-data-tools/social-deprivation-index.html

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