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Review
. 2025 Jun:82:102523.
doi: 10.1016/j.coph.2025.102523. Epub 2025 Mar 21.

Lipids and lipid regulators in intraocular pressure homeostasis

Gregory T Rognon  1 , Anna Yu-An Liao  2 , Rodahina Philihina Pasteurin  1 , Avinash Soundararajan  1 , Padmanabhan Paranji Pattabiraman  3
Affiliations
Review

Lipids and lipid regulators in intraocular pressure homeostasis

Gregory T Rognon et al. Curr Opin Pharmacol. 2025 Jun.

Abstract

Increased intraocular pressure is the strongest correlated modifiable risk factor for developing primary open-angle glaucoma (POAG). Lipids have long been known to be a major constituent of aqueous humor. Lipid mediators, prostaglandins for example, are the first-line treatment for glaucoma. Innovative technologies have made the investigation of lipids in small quantities possible, and interest in identifying lipids as new pharmacological targets has grown in ophthalmology. There is expanding evidence to suggest that lipids and their active metabolites play a role in POAG pathophysiology, as differences between control and diseased eyes have now been demonstrated. The role of these differences is yet to be determined and is the subject of this review.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no conflict of interest. The funders had no role in the writing of the manuscript.

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