Upper Respiratory Microbiome in Vasculitis

Abstract

The pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), such as granulomatosis with polyangiitis, is not well understood. These diseases cause significant inflammation in the upper airway. The nares and upper airway are host to many commensal microbes as well as a frequent site of exposure to pathogenic microbes. This review explores the association between upper airway microbial dysregulation and AAV. The role of Staphylococcus aureus colonization as a possible driver of disease is discussed, as well as recent work exploring how fluctuations in the abundance and diversity of commensal microbes are related to vasculitis and risk of flare.

Keywords: ANCA; GPA; Microbiome; Upper airway; Vasculitis.