First-line chemotherapies administered before hematopoietic cell transplantation in children with acute leukemia: effect on the spermatogonial pool

A S Gille^#^{1

2

3}, L Lenez^#^{2

4}, A Vanhæsebrouck^{5

6

7}, D Rivet-Danon⁸, C Lapoujade^{9

10}, L Riou^{9

10}, J H Dalle^{1

11}, K Yakouben¹¹, M Peycelon^{1

12}, M Fahd¹¹, A Paye-Jaouen¹², G Leverger^{13

14}, M D Tabone¹⁴, H Boutroux^{13

14}, S Irtan^{13

15}, C Chenouf², M Sibony^{1

16}, C Chalas^{2

3}, C Patrat^{1

2

3}, J P Wolf^{1

2

3}, N Boissel^{1

17}, P Fouchet^{9

10}, C Poirot^#^{3

13

14}, V Barraud-Lange^#^{18

19

20}

Affiliations

¹ University Paris Cité, Paris, France.
² Team From Gametes To Birth. Departments Genetic and cellular plasticity. Metabolism and endocrinology. Cochin Institute, INSERM U1016, Paris, France.
³ AP-HP.Center-University Paris Cité. Cochin Hospital. Department of Reproductive Biology CECOS, Paris, France.
⁴ Gustave Roussy. Department of pediatric and adolescent oncology, Villejuif, France.
⁵ Sorbonne Paris North University, Interdisciplinary Research Institute on Social issues (IRIS), UMR 8156-997, Aubervilliers, France.
⁶ AP-HP, Jean-Verdier Hospital, Department of legal and social Medicine, 93140, Bondy, France.
⁷ Sorbonne University, INSERM, Pierre Louis Institute of Epidemiology and Public Health, Department of Social Epidemiology, Paris, France.
⁸ AP-HP. Sorbonne University. Tenon Hospital. Department of Reproductive Biology CECOS, Paris, France.
⁹ Paris Cité University, CEA, Genetic Stability, Stem Cells and Radiation, Laboratory of Germinal Stem Cells, Fontenay-aux-, Roses, France.
¹⁰ Paris-Saclay University, CEA, Genetic Stability, Stem Cells and Radiation, Laboratory of Germinal Stem Cells, Fontenay-aux-, Roses, France.
¹¹ APHP.North-University Paris Cité. Robert Debré University Hospital. Department of Pediatric Immunology and Hematology, Paris, France.
¹² APHP.North-University Paris Cité. Robert Debré University Hospital. Department of Pediatric Surgery and Urology. Centre de Référence des Malformations Rares des Voies Urinaires (MARVU), ERN eUROGEN accredited center, Inserm UMR 1141 NeuroDev, Paris, France.
¹³ Sorbonne University, Paris, France.
¹⁴ AP-HP.Sorbonne University. Armand Trousseau Hospital. Department of Pediatric Onco-Hematology, Paris, France.
¹⁵ AP-HP.Sorbonne University. Armand Trousseau Hospital. Department of Visceral Pediatric Surgery, Paris, France.
¹⁶ AP-HP.Center-University Paris Cité. Cochin Hospital, Paris, France.
¹⁷ AP-HP.North-University Paris Cité. Saint-Louis Hospital. Department of Hematology, Adolescents and Young Adults Unit, Paris, France.
¹⁸ Team From Gametes To Birth. Departments Genetic and cellular plasticity. Metabolism and endocrinology. Cochin Institute, INSERM U1016, Paris, France. virginie.barraud-lange@aphp.fr.
¹⁹ AP-HP.Center-University Paris Cité. Cochin Hospital. Department of Reproductive Biology CECOS, Paris, France. virginie.barraud-lange@aphp.fr.
²⁰ AP-HP.North-University Paris Cité. Saint-Louis Hospital. Department of Hematology, Adolescents and Young Adults Unit, Paris, France. virginie.barraud-lange@aphp.fr.

^# Contributed equally.

PMID: 40246945
DOI: 10.1038/s41409-025-02547-9

First-line chemotherapies administered before hematopoietic cell transplantation in children with acute leukemia: effect on the spermatogonial pool

A S Gille et al. Bone Marrow Transplant. 2025 Jun.

. 2025 Jun;60(6):927-931.

doi: 10.1038/s41409-025-02547-9. Epub 2025 Apr 17.

Authors

Affiliations

¹ University Paris Cité, Paris, France.
² Team From Gametes To Birth. Departments Genetic and cellular plasticity. Metabolism and endocrinology. Cochin Institute, INSERM U1016, Paris, France.
³ AP-HP.Center-University Paris Cité. Cochin Hospital. Department of Reproductive Biology CECOS, Paris, France.
⁴ Gustave Roussy. Department of pediatric and adolescent oncology, Villejuif, France.
⁵ Sorbonne Paris North University, Interdisciplinary Research Institute on Social issues (IRIS), UMR 8156-997, Aubervilliers, France.
⁶ AP-HP, Jean-Verdier Hospital, Department of legal and social Medicine, 93140, Bondy, France.
⁷ Sorbonne University, INSERM, Pierre Louis Institute of Epidemiology and Public Health, Department of Social Epidemiology, Paris, France.
⁸ AP-HP. Sorbonne University. Tenon Hospital. Department of Reproductive Biology CECOS, Paris, France.
⁹ Paris Cité University, CEA, Genetic Stability, Stem Cells and Radiation, Laboratory of Germinal Stem Cells, Fontenay-aux-, Roses, France.
¹⁰ Paris-Saclay University, CEA, Genetic Stability, Stem Cells and Radiation, Laboratory of Germinal Stem Cells, Fontenay-aux-, Roses, France.
¹¹ APHP.North-University Paris Cité. Robert Debré University Hospital. Department of Pediatric Immunology and Hematology, Paris, France.
¹² APHP.North-University Paris Cité. Robert Debré University Hospital. Department of Pediatric Surgery and Urology. Centre de Référence des Malformations Rares des Voies Urinaires (MARVU), ERN eUROGEN accredited center, Inserm UMR 1141 NeuroDev, Paris, France.
¹³ Sorbonne University, Paris, France.
¹⁴ AP-HP.Sorbonne University. Armand Trousseau Hospital. Department of Pediatric Onco-Hematology, Paris, France.
¹⁵ AP-HP.Sorbonne University. Armand Trousseau Hospital. Department of Visceral Pediatric Surgery, Paris, France.
¹⁶ AP-HP.Center-University Paris Cité. Cochin Hospital, Paris, France.
¹⁷ AP-HP.North-University Paris Cité. Saint-Louis Hospital. Department of Hematology, Adolescents and Young Adults Unit, Paris, France.
¹⁸ Team From Gametes To Birth. Departments Genetic and cellular plasticity. Metabolism and endocrinology. Cochin Institute, INSERM U1016, Paris, France. virginie.barraud-lange@aphp.fr.
¹⁹ AP-HP.Center-University Paris Cité. Cochin Hospital. Department of Reproductive Biology CECOS, Paris, France. virginie.barraud-lange@aphp.fr.
²⁰ AP-HP.North-University Paris Cité. Saint-Louis Hospital. Department of Hematology, Adolescents and Young Adults Unit, Paris, France. virginie.barraud-lange@aphp.fr.

^# Contributed equally.

PMID: 40246945
DOI: 10.1038/s41409-025-02547-9

No abstract available

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Conflict of interest statement

Competing interests: The authors declare no competing interests. Informed consent: Parents (or Legal guardians) provided their informed consent for the use of their children’s medical data in the present study.

References

1. Rasche M, Zimmermann M, Borschel L, Bourquin JP, Dworzak M, Klingebiel T, et al. Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012. Leukemia. 2018;32:2167–77. - DOI - PubMed - PMC
1. Mathiesen S, Sørensen K, Nielsen MM, Suominen A, Ifversen M, Grell K, et al. Male Gonadal Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Cross-Sectional, Population-Based Study. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2020;26:1635–45. - DOI
1. Chow EJ, Stratton KL, Leisenring WM, Oeffinger KC, Sklar CA, Donaldson SS, et al. Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort. Lancet Oncol. 2016;17:567–76. - DOI - PubMed - PMC
1. Rives N, Courbière B, Almont T, Kassab D, Berger C, Grynberg M, et al. What should be done in terms of fertility preservation for patients with cancer? The French 2021 guidelines. Eur J Cancer Oxf Engl. 2022;173:146–66. - DOI
1. Poganitsch-Korhonen M, Masliukaite I, Nurmio M, Lähteenmäki P, van Wely M, van Pelt AMM, et al. Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents. Leukemia. 2017;31:1460–3. - DOI - PubMed - PMC

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First-line chemotherapies administered before hematopoietic cell transplantation in children with acute leukemia: effect on the spermatogonial pool

Affiliations

First-line chemotherapies administered before hematopoietic cell transplantation in children with acute leukemia: effect on the spermatogonial pool

Authors

Affiliations

Conflict of interest statement

References

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LinkOut - more resources

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