Five-year drug survival of dupilumab in atopic dermatitis: Italian landscape AD real-world study

Luigi Gargiulo^{1

2}, Silvia M Ferrucci³, Luciano Ibba^{1

2}, Ruggero Cascio Ingurgio^{1

2}, Angela Alfano^{1

2}, Giuseppe F Amoruso⁴, Anna Balato⁵, Tania Barbagallo⁶, Francesca Barei³, Francesco Bellinato⁷, Pina Brianti⁸, Anna G Burroni⁹, Anna Campanati¹⁰, Francesca Caroppo¹¹, Andrea Carugno¹², Giacomo Dal Bello¹³, Francesco De Franco¹⁴, Anna Belloni Fortina¹⁵, Caterina Foti¹⁶, Francesca M Gaiani¹⁷, Giampiero Girolomoni⁷, Massimo Gola¹⁸, Mario B Guanti¹⁹, Carlotta Gurioli^{20

21}, Agostina Legori²², Francesco Loconsole¹⁶, Elisabetta Magnaterra¹⁸, Piergiorgio Malagoli¹⁷, Flavia Manzo Margiotta²³, Angelo V Marzano^{3

24}, Santo R Mercuri^{8

25}, Nicola Milanesi²⁶, Maria L Musumeci²⁷, Maddalena Napolitano²⁸, Michela Ortoncelli²⁹, Giovanni Paolino⁸, Cataldo Patruno³⁰, Paolo Pella³¹, Elena Pezzolo³², Francesca Prestinari³³, Sebastiano Recalcati⁶, Simone Ribero²⁹, Franco Rongioletti²⁵, Mariateresa Rossi³⁴, Francesca Satolli¹⁴, Paola Savoia³⁵, Claudio Sciarrone³⁶, Cristina Spigariolo^{3

24}, Giorgio Stabile²⁵, Benedetta Tirone¹⁶, Ersilia Tolino³⁷, Nicola Zerbinati³⁸, Concetta Potenza³⁷, Antonio Costanzo^{1

2}, Alessandra Narcisi¹

Affiliations

¹ Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
² Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
³ Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
⁴ Dermatology Unit, Azienda Ospedaliera di Cosenza, Italy.
⁵ Dermatology Unit, University of Campania L. Vanvitelli, Naples, Italy.
⁶ Dermatology Unit, ASST Lecco, Alessandro Manzoni Hospital, Lecco, Italy.
⁷ Department of Medicine, Section of Dermatology and Venereology, Università Degli Studi di Verona, Verona, Italy.
⁸ Dermatology and Cosmetology Unit, IRCCS San Raffaele Hospital, Milan, Italy.
⁹ Section of Dermatology, Department of Health Sciences (Di.S.Sal), University of Genoa, IRCCS-San Martino Polyclinic Hospital, Genoa, Italy.
¹⁰ Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
¹¹ Dermatology Unit, Department of Medicine DIMED & Pediatric Dermatology Regional Center, Department of Women and Children's Health (SDB), University of Padua, Padua, Italy.
¹² Department of Medicine and Surgery, University of Insubria, Varese, Italy.
¹³ Section of Dermatology, Department of Medicine, ASST di Mantova, Mantova, Italy.
¹⁴ Unit of Dermatology, University of Parma, Parma, Italy.
¹⁵ Pediatric Dermatology Regional Center, Department of Women and Children's Health (SDB), University of Padua, Padua, Italy.
¹⁶ Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", Bari, Italy.
¹⁷ Department of Dermatology, Dermatology Unit Azienda Ospedaliera San Donato Milanese, Milan, Italy.
¹⁸ Allergological and Pediatric Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.
¹⁹ Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
²⁰ Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
²¹ Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
²² UO Dermatologia IRCCS Ospedale Galeazzi & Università Degli Studi di Milano, Milan, Italy.
²³ Department of Dermatology, University of Pisa, Pisa, Italy.
²⁴ Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, Milan, Italy.
²⁵ Dermatology Clinic, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
²⁶ Department of Dermatology, San Jacopo Hospital, Pistoia, Italy.
²⁷ Dermatology Clinic, University of Catania, Catania, Italy.
²⁸ Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
²⁹ Department of Medical Sciences, Dermatology Clinic, University of Turin, Turin, Italy.
³⁰ Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
³¹ Dermatologia, Ospedale Degli Infermi, Biella, Italy.
³² Department of Dermatology, San Bortolo Hospital, Vicenza, Italy.
³³ Valduce Hospital, Como, Italy.
³⁴ Dermatology Unit, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy.
³⁵ Dermatology Clinic, Department of Health Science, University of Eastern Piedmont, Novara, Italy.
³⁶ Department of Dermatology, Papardo Hospital, Messina, Italy.
³⁷ Unit of Dermatology, Department of Medical-Surgical Science and Biotechnologies, Sapienza University of Rome, A. Fiorini Hospital, Latina, Italy.
³⁸ Department of Medicine and Innovation Technology (DiMIT), University of Insubria, Varese, Italy.

PMID: 40247595
DOI: 10.1111/jdv.20699

Five-year drug survival of dupilumab in atopic dermatitis: Italian landscape AD real-world study

Luigi Gargiulo et al. J Eur Acad Dermatol Venereol. 2025 Sep.

. 2025 Sep;39(9):e807-e811.

doi: 10.1111/jdv.20699. Epub 2025 Apr 17.

Authors

Affiliations

¹ Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
² Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
³ Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
⁴ Dermatology Unit, Azienda Ospedaliera di Cosenza, Italy.
⁵ Dermatology Unit, University of Campania L. Vanvitelli, Naples, Italy.
⁶ Dermatology Unit, ASST Lecco, Alessandro Manzoni Hospital, Lecco, Italy.
⁷ Department of Medicine, Section of Dermatology and Venereology, Università Degli Studi di Verona, Verona, Italy.
⁸ Dermatology and Cosmetology Unit, IRCCS San Raffaele Hospital, Milan, Italy.
⁹ Section of Dermatology, Department of Health Sciences (Di.S.Sal), University of Genoa, IRCCS-San Martino Polyclinic Hospital, Genoa, Italy.
¹⁰ Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
¹¹ Dermatology Unit, Department of Medicine DIMED & Pediatric Dermatology Regional Center, Department of Women and Children's Health (SDB), University of Padua, Padua, Italy.
¹² Department of Medicine and Surgery, University of Insubria, Varese, Italy.
¹³ Section of Dermatology, Department of Medicine, ASST di Mantova, Mantova, Italy.
¹⁴ Unit of Dermatology, University of Parma, Parma, Italy.
¹⁵ Pediatric Dermatology Regional Center, Department of Women and Children's Health (SDB), University of Padua, Padua, Italy.
¹⁶ Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", Bari, Italy.
¹⁷ Department of Dermatology, Dermatology Unit Azienda Ospedaliera San Donato Milanese, Milan, Italy.
¹⁸ Allergological and Pediatric Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.
¹⁹ Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
²⁰ Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
²¹ Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
²² UO Dermatologia IRCCS Ospedale Galeazzi & Università Degli Studi di Milano, Milan, Italy.
²³ Department of Dermatology, University of Pisa, Pisa, Italy.
²⁴ Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, Milan, Italy.
²⁵ Dermatology Clinic, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
²⁶ Department of Dermatology, San Jacopo Hospital, Pistoia, Italy.
²⁷ Dermatology Clinic, University of Catania, Catania, Italy.
²⁸ Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
²⁹ Department of Medical Sciences, Dermatology Clinic, University of Turin, Turin, Italy.
³⁰ Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
³¹ Dermatologia, Ospedale Degli Infermi, Biella, Italy.
³² Department of Dermatology, San Bortolo Hospital, Vicenza, Italy.
³³ Valduce Hospital, Como, Italy.
³⁴ Dermatology Unit, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy.
³⁵ Dermatology Clinic, Department of Health Science, University of Eastern Piedmont, Novara, Italy.
³⁶ Department of Dermatology, Papardo Hospital, Messina, Italy.
³⁷ Unit of Dermatology, Department of Medical-Surgical Science and Biotechnologies, Sapienza University of Rome, A. Fiorini Hospital, Latina, Italy.
³⁸ Department of Medicine and Innovation Technology (DiMIT), University of Insubria, Varese, Italy.

PMID: 40247595
DOI: 10.1111/jdv.20699

No abstract available

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References

REFERENCES

1. Boesjes CM, Kamphuis E, de Graaf M, Spekhorst LS, Haeck I, van der Gang LF, et al. Long‐term effectiveness and reasons for discontinuation of Dupilumab in patients with atopic dermatitis. JAMA Dermatol. 2024;160(10):1044–1055. https://doi.org/10.1001/jamadermatol.2024.2517
1. Wollenberg A, Kinberger M, Arents B, Aszodi N, Avila Valle G, Barbarot S, et al. European guideline (EuroGuiDerm) on atopic eczema: part I‐systemic therapy. J Eur Acad Dermatol Venereol. 2022;36(9):1409–1431. https://doi.org/10.1111/jdv.18345
1. Gargiulo L, Ibba L, Malagoli P, Burroni AG, Chiricozzi A, Dapavo P, et al. Management of patients affected by moderate‐to‐severe atopic dermatitis with JAK inhibitors in real‐world clinical practice: an Italian Delphi consensus. Dermatol Ther. 2024;14(4):919–932. https://doi.org/10.1007/s13555‐024‐01135‐x
1. European Medicines Agency. Dupixent (dupilumab): summary of product characteristics; 2017. Available from: https://www.ema.europa.eu/en/medicines/human/EPAR/dupixent. [Accessed 29 October 2024]
1. Agenzia Italiana del Farmaco (AIFA). Dupixent (dupilumab). Available from: https://www.aifa.gov.it/documents/20142/961234/Determina_646‐2024_Dupilu... [Accessed 2025 January 28]

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Five-year drug survival of dupilumab in atopic dermatitis: Italian landscape AD real-world study

Affiliations

Five-year drug survival of dupilumab in atopic dermatitis: Italian landscape AD real-world study

Authors

Affiliations

References

REFERENCES

Publication types

LinkOut - more resources

Full Text Sources