Multimodal treatment for colorectal liver metastases: A toolbox for clinicians

Abstract

Colorectal cancer is the second most common cause of cancer-related death worldwide, and liver metastases are the leading cause of mortality in these patients. Surgical innovations combined with modern systemic chemotherapy have improved 5-year overall survival rates. This review aims to equip non-hepatobiliary surgeons with a comprehensive toolbox for the diagnosis and management of colorectal liver metastases. It covers the current landscape of diagnostic workup, including imaging modalities and biomarkers, and reviews the surgical and nonsurgical treatment options. This guide attempts to enhance multidisciplinary care for patients with colorectal liver metastases by integrating evidence-based practices with innovative strategies, which can improve outcomes and survival.

Keywords: ALPPS; Colorectal cancer liver metastases; hepatic artery infusion pump therapy; liver surgery; liver transplant; minimal invasive liver surgery; thermal ablation.