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Case Reports
. 2025 Apr 8;20(6):3144-3147.
doi: 10.1016/j.radcr.2025.03.025. eCollection 2025 Jun.

NK/T-cell bone lymphoma-induced hemophagocytic lymphohistiocytosis: A clinical case report

Zhanrong Zhang  1 , Feng Chen  1
Affiliations
Case Reports

NK/T-cell bone lymphoma-induced hemophagocytic lymphohistiocytosis: A clinical case report

Zhanrong Zhang et al. Radiol Case Rep. .

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a severe condition characterized by the secretion of large amounts of inflammatory cytokines. Lymphoma is a major cause of secondary HLH. This report describes the case of a child initially diagnosed with HLH who experienced recurrent episodes after treatment. Ten months after the initial diagnosis, a mass was discovered in the right upper limb, and pathology findings confirmed NK/T-cell lymphoma. Based on the patient's medical history, this lymphoma was considered the underlying cause of HLH. Patients diagnosed with lymphoma complicated by HLH have a worse prognosis and shorter survival compared with those without HLH. Early diagnosis and timely symptomatic treatment can significantly improve patient prognosis.

Keywords: Bone lymphoma; Case report; Hemophagocytic lymphohistiocytosis; NK/T-cell lymphoma.

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Figures

Fig 1
Fig. 1
X-ray and CT images of the right upper extremity. A red circle indicates a slight periosteal reaction on the bone cortex's edge.
Fig 2
Fig. 2
Magnetic resonance images of the right upper extremity, representative of the study.
See this image and copyright information in PMC

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