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Case Reports
. 2025 Apr 8;20(6):3144-3147.
doi: 10.1016/j.radcr.2025.03.025. eCollection 2025 Jun.

NK/T-cell bone lymphoma-induced hemophagocytic lymphohistiocytosis: A clinical case report

Zhanrong Zhang  1 , Feng Chen  1
Affiliations
Case Reports

NK/T-cell bone lymphoma-induced hemophagocytic lymphohistiocytosis: A clinical case report

Zhanrong Zhang et al. Radiol Case Rep. .

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a severe condition characterized by the secretion of large amounts of inflammatory cytokines. Lymphoma is a major cause of secondary HLH. This report describes the case of a child initially diagnosed with HLH who experienced recurrent episodes after treatment. Ten months after the initial diagnosis, a mass was discovered in the right upper limb, and pathology findings confirmed NK/T-cell lymphoma. Based on the patient's medical history, this lymphoma was considered the underlying cause of HLH. Patients diagnosed with lymphoma complicated by HLH have a worse prognosis and shorter survival compared with those without HLH. Early diagnosis and timely symptomatic treatment can significantly improve patient prognosis.

Keywords: Bone lymphoma; Case report; Hemophagocytic lymphohistiocytosis; NK/T-cell lymphoma.

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Figures

Fig 1
Fig. 1
X-ray and CT images of the right upper extremity. A red circle indicates a slight periosteal reaction on the bone cortex's edge.
Fig 2
Fig. 2
Magnetic resonance images of the right upper extremity, representative of the study.
See this image and copyright information in PMC

References

    1. Ponnatt T.S., Lilley C.M., Mirza K.M. Hemophagocytic lymphohistiocytosis. Arch Pathol Lab Med. 2022;146(4):507–519. doi: 10.5858/arpa.2020-0802-RA. - DOI - PubMed
    1. Kanegane H., Noguchi A., Yamada Y., Yasumi T. Rare diseases presenting with hemophagocytic lymphohistiocytosis. Pediatr Int. 2023;65(1):e15516. doi: 10.1111/ped.15516. - DOI - PubMed
    1. Janka G.E. History of hemophagocytic lymphohistiocytosis. Adv Exp Med Biol. 2024;1448:9–19. doi: 10.1007/978-3-031-59815-9_2. - DOI - PubMed
    1. Ou W., Zhao Y., Wei A., et al. Subcutaneous panniculitis-like T-cell lymphoma associated with hemophagocytic lymphohistiocytosis: a systematic review of 63 patients reported in the literature. Clin Exp Med. 2023;23(8):4575–4583. doi: 10.1007/s10238-023-01210-1. - DOI - PubMed
    1. Tran N.T., Nguyen K.T., Le L.T., Nguyen K.T., Trinh C.T., Hoang V.T. Subcutaneous panniculitis-like T-cell lymphoma with hemophagocytic lymphohistiocytosis. J Investig Med High Impact Case Rep. 2024;12 doi: 10.1177/23247096241253337. - DOI - PMC - PubMed

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