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. 2025 Apr 16;13(4):e70447.
doi: 10.1002/ccr3.70447. eCollection 2025 Apr.

Plummer-Vinson Syndrome With Coexistent Thyro-Cardiac Disease and Acute Decompensated Heart Failure: A Case Report

Suleiman Ayalew  1 , Michael A Negussie  2 , Tinsae Anebo  3 , Fitsum A Gemechu  2 , Yishak Abdulsemed  1 , Segenet B Mengistu  4
Affiliations

Plummer-Vinson Syndrome With Coexistent Thyro-Cardiac Disease and Acute Decompensated Heart Failure: A Case Report

Suleiman Ayalew et al. Clin Case Rep. .

Abstract

Plummer-Vinson Syndrome (PVS) is a rare disorder characterized by the triad of dysphagia, iron-deficiency anemia, and esophageal webs. Limited data on its prevalence exist, with most information derived from case reports. We present the case of a 60-year-old woman with a 6-month history of a progressively enlarging anterior neck mass and worsening symptoms of heart failure, heat intolerance, and dysphagia. Diagnostic evaluation revealed a multinodular goiter, microcytic hypochromic anemia, hyperthyroidism, hypokalemia, and esophageal webs. She was diagnosed with PVS in conjunction with thyro-cardiac disease and acute decompensated heart failure. Treatment included iron supplementation, pneumatic dilation, and management of her thyroid and cardiac conditions, resulting in significant clinical improvement. This case demonstrates the importance of early recognition and treatment of PVS to prevent complications and reduce morbidity.

Keywords: Plummer‐Vinson syndrome; case report; esophageal web; thyro‐cardiac disease.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Upper GI endoscopy revealing esophageal webs.
FIGURE 2
FIGURE 2
Barium swallow showing focal esophageal dilatation with an incomplete linear filling defect caused by the esophageal webs.
See this image and copyright information in PMC

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