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Case Reports
. 2025 Jan-Mar;29(1):158-162.
doi: 10.4103/jomfp.jomfp_138_24. Epub 2025 Mar 28.

Angioleiomyoma of cheek - A case report highlighting immunohistochemical diagnostic approach

Shamala Sivanandham  1 , Sri Sruthi Preman  2 , Adhithya Baskaran  3 , Kokila Sivakumar  3
Affiliations
Case Reports

Angioleiomyoma of cheek - A case report highlighting immunohistochemical diagnostic approach

Shamala Sivanandham et al. J Oral Maxillofac Pathol. 2025 Jan-Mar.

Abstract

Benign smooth muscle tumours, known as leiomyomas, are comparatively frequent, with uterine cases accounting for 95% incidence. Oral leiomyomas typically appear as asymptomatic, slowly-growing submucosal lumps in the tongue, hard palate, or buccal mucosa. Three histologic kinds of leiomyomas are recognized: epithelioid leiomyoma, solid leiomyoma, and angioleiomyoma. The most prevalent type of leiomyomas affecting the oral cavity are solitary forms called angioleiomyomas, which typically develop in the subcutis. The diagnosis is commonly determined by histopathological and Immunohistochemistry (IHC) procedures. This case reports a 30-year-old female patient with a lesion on her right cheek region. The postsurgical specimen was routinely processed and stained with hematoxylin and eosin staining, and IHC studies confirmed the diagnosis of 'Benign spindle cell neoplasm-Angioleiomyoma'.

Keywords: Angioleiomyoma; benign spindle cell neoplasm; immunohistochemistry; leiomyoma.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Extra oral swelling
Figure 2
Figure 2
Intra oral
Figure 3
Figure 3
Ultrasound image
Figure 4
Figure 4
Macroscopic features showing multiple bits of soft tissue specimen
Figure 5
Figure 5
(a) Histopathological features (20x), (b) Histopathological features (40x)
See this image and copyright information in PMC

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