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Review
. 2024 Sep 11;6(2):72-76.
doi: 10.14744/hf.2024.2024.0003. eCollection 2025.

Drug-induced liver injury: Diagnosis, management and the role of liver transplantation

Nazli Begum Ozturk  1 , Eren Uskudar  2 , Merih Deniz Toruner  3 , Cem Simsek  2 , Ahmet Gurakar  2
Affiliations
Review

Drug-induced liver injury: Diagnosis, management and the role of liver transplantation

Nazli Begum Ozturk et al. Hepatol Forum. .

Abstract

Drug-induced liver injury (DILI) is caused by various medications or herbals/nutritional supplements resulting in liver test abnormalities or hepatic dysfunction. DILI can be categorized as direct (intrinsic), idiosyncratic, or immune-mediated (indirect), and patterns of injury can be categorized as hepatocellular, cholestatic, or mixed injury. DILI is diagnosed after excluding other causes of liver injury. Cessation of the suspected drug along with supportive care is recommended for most DILI cases. In life-threatening situations, liver transplantation (LT) can be considered; however, the risks with LT and lifelong immunosuppression should be considered. In this paper, we summarize the pathophysiology, diagnosis, medical management, and LT for DILI.

Keywords: Liver failure; liver injury; toxic hepatitis.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Pathogenesis of DILI.
Figure 2
Figure 2
Types of DILI and schematic of the outcomes.
See this image and copyright information in PMC

References

    1. Hosack T, Damry D, Biswas S. Drug-induced liver injury: a comprehensive review. Therap Adv Gastroenterol. 2023 Mar 21;16:17562848231163410. doi: 10.1177/17562848231163410. - DOI - PMC - PubMed
    1. Fontana RJ, Liou I, Reuben A, Suzuki A, Fiel MI, Lee W, et al. AASLD practice guidance on drug, herbal, and dietary supplement-induced liver injury. Hepatology. 2023;77(3):1036–1065. doi: 10.1002/hep.32689. - DOI - PMC - PubMed
    1. Björnsson H, Björnsson E. Drug-induced liver injury: Pathogenesis, epidemiology, clinical features, and practical management. European Journal of Internal Medicine. 2022;97:26–31. doi: 10.1016/j.ejim.2021.10.035. - DOI - PubMed
    1. Hoofnagle JH, Björnsson ES. Drug-induced liver injury-types and phenotypes. N Eng J Med. 2019;381(3):264–273. doi: 10.1056/NEJMra1816149. - DOI - PubMed
    1. Gerussi A, Natalini A, Antonangeli F, Mancuso C, Agostinetto E, Barisani D, et al. Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models. Int J Mol Sci. 2021;22(9):4557. doi: 10.3390/ijms22094557. - DOI - PMC - PubMed

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