Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 17;64(25):e202425588.
doi: 10.1002/anie.202425588. Epub 2025 Apr 25.

Saarvienin A-A Novel Glycopeptide with Potent Activity against Drug-Resistant Bacteria

Amninder Kaur #  1   2 , Jaime Felipe Guerrero-Garzón #  3 , Sari Rasheed #  1   2 , Martin Zehl  4 , Franziska Fries  1   2 , Bernd Morgenstern  5 , Sergey B Zotchev  3 , Rolf Müller  1   2   6
Affiliations

Saarvienin A-A Novel Glycopeptide with Potent Activity against Drug-Resistant Bacteria

Amninder Kaur et al. Angew Chem Int Ed Engl. .

Abstract

A member of a new family of glycopeptides, named saarvienin A, was isolated from a rare actinomycete Amycolatopsis sp. YIM10. Extensive NMR and MS analyses revealed a halogenated peptide core comprising four amino acids cyclized via a ureido linkage with an exocyclic 2-hydroxy-3-(4-hydroxyphenyl)propyl residue connected to a five-sugar/aminosugar chain. Two of the three aminosugars constitute the N-methylated and N,O-dimethylated derivatives of eremosamine (4-epi-vancosamine) that have not been reported in any natural product. Saarvienin A exhibits potent activity against a range of Gram-positive bacteria, effectively overcoming resistance to several frontline antibiotics in clinical isolates. It demonstrates an eight-fold reduction in minimum inhibitory concentrations (MICs) against methicillin-resistant, vancomycin-intermediate, and daptomycin-resistant Staphylococcus aureus compared to vancomycin.

Keywords: Amycolatopsis sp; Glycopeptide antibiotic; Gram‐positive bacteria; Structure elucidation; Vancomycin‐resistance.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of saarvienin A (1).
Figure 2
Figure 2
Key HMBC correlations (→) and HRMSMS data used to establish the connectivity of various units in saarvienin A (1).
See this image and copyright information in PMC

References

    1. Butler M. S., Hansford K. A., Blaskovich M. A. T., Halai R., Cooper M. A., J. Antibiot. 2014, 67, 631–644. - PubMed
    1. Marcone G. L., Binda E., Berini F., Marinelli F., Biotechnol. Adv. 2018, 36, 534–554. - PubMed
    1. Zeng D., Debabov D., Hartsell T. L., Cano R. J., Adams S., Schuyler J. A., McMillan R., Pace J. L., Cold Spring Harb. Perspect. Med. 2016, 6, a026989. - PMC - PubMed
    1. Nicolaou K. C., Boddy C. N. C., Bräse S., Winssinger N., Angew. Chem. Int. Ed. 1999, 38, 2096–2152. - PubMed
    1. Kahne D., Leimkuhler C., Lu W., Walsh C., Chem. Rev. 2005, 105, 425–448. - PubMed

MeSH terms

LinkOut - more resources