Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025:2915:189-200.
doi: 10.1007/978-1-0716-4466-9_13.

Bilateral Optogenetic Stimulation of the Olfactory Bulb of OMP-ChIEF Mice

Praveen Kuruppath  1
Affiliations

Bilateral Optogenetic Stimulation of the Olfactory Bulb of OMP-ChIEF Mice

Praveen Kuruppath. Methods Mol Biol. 2025.

Abstract

Optogenetics has revolutionized the field of neuroscience by enabling the manipulation of specific neuronal populations with exceptional precision. Here, a robust method is described that integrates optogenetic stimulation of olfactory bulb glomeruli with foot shock fear conditioning. By merging the sophistication of optogenetics with the well-established principles of fear conditioning, this method opens new avenues for exploring the neural dynamics that drive adaptive behavioral responses to olfactory threats.

Keywords: Channelrhodopsin-2; Foot shock; Light zone; Olfactory bulb; Optogenetics; Safe zone.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Catania KC (2013) Stereo and serial sniffing guide navigation to an odour source in a mammal. Nat Commun 4:1441 - DOI - PubMed
    1. Erofeev A, Gerasimov E, Lavrova A, Bolshakova A, Postnikov E, Bezprozvanny I, Vlasova OL (2019) Light stimulation parameters determine neuron dynamic characteristics. Appl Sci (Switz) 9:3673 - DOI
    1. Esquivelzeta Rabell J, Mutlu K, Noutel J, Martin del Olmo P, Haesler S (2017) Spontaneous rapid odor source localization behavior requires interhemispheric communication. Curr Biol 27:1542–1548.e4 - DOI - PubMed
    1. Kepple DR, Giaffar H, Rinberg D, Koulakov AA (2019) Deconstructing odorant identity via primacy in dual networks. Neural Comput 31:710–737 - DOI - PubMed - PMC
    1. Li A, Gire DH, Bozza T, Restrepo D (2014) Precise detection of direct glomerular input duration by the olfactory bulb. J Neurosci 34:16058–16064 - DOI - PubMed - PMC

LinkOut - more resources