Now you see me, now you don't: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors
- PMID: 40250409
- DOI: 10.1016/j.molcel.2025.03.019
Now you see me, now you don't: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors
Abstract
In a recent issue of Molecular Cell, Genoyer et al.1 show that during West Nile virus infection, escaped, cytoplasmic, anti-genomic negative-sense viral RNA triggers an antiviral response via RIG-I activation. Flaviviruses typically hide -vRNA in replication compartments to avoid detection, but some -vRNA leaks, possibly aided by viral capsid proteins.
Copyright © 2025 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
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