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. 2025 Apr 17;85(8):1482-1483.
doi: 10.1016/j.molcel.2025.03.019.

Now you see me, now you don't: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors

Raul Andino  1 , Daniel Darling  2
Affiliations

Now you see me, now you don't: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors

Raul Andino et al. Mol Cell. .

Abstract

In a recent issue of Molecular Cell, Genoyer et al.1 show that during West Nile virus infection, escaped, cytoplasmic, anti-genomic negative-sense viral RNA triggers an antiviral response via RIG-I activation. Flaviviruses typically hide -vRNA in replication compartments to avoid detection, but some -vRNA leaks, possibly aided by viral capsid proteins.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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