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. 2025 Aug 1;437(15):169158.
doi: 10.1016/j.jmb.2025.169158. Epub 2025 Apr 16.

PANDA: PAN Cancer Data Analysis Web Tool

G Pepe  1 , C Notturno Granieri  2 , R Appierdo  3 , G Ausiello  2 , M Helmer-Citterich  4 , P F Gherardini  5
Affiliations
Free article

PANDA: PAN Cancer Data Analysis Web Tool

G Pepe et al. J Mol Biol. .
Free article

Abstract

Cancer research faces challenges due to the genetic diversity within tumors and individual variability. Precision medicine aims to identify genomic and molecular factors linked to clinical outcomes, leveraging large datasets for drug discovery and patient stratification. We introduce PANDA (PAN-cancer Data Analysis web tool) (https://panda.bio.uniroma2.it), a web server designed for analyzing TCGA genomic data. A total of 32 tumor types and 10,711 samples were selected for this analysis. PANDA simplifies complex tasks such as differential expression, survival analysis, and patient stratification, incorporating clinical factors like sex, stage, and treatment history. It also enables the exploration of biological pathways and immune cell type proportion, providing insights into tumor progression. PANDA is user-friendly, designed for researchers with limited informatics expertise, and supports diverse analyses to advance cancer research.

Keywords: TCGA patient stratification; cancer biology; cancer genomics; immune cell deconvolution; pan-cancer analysis.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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