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. 2025 Jun 30;40(7):1439-1441.
doi: 10.1093/ndt/gfaf063.

Early identification of CKD in patients with solitary functioning kidney

Luigi Cirillo  1 , Tommaso Mazzierli  2 , Alessandra Bettiol  3 , Andrea La Tessa  1   4 , Marco Moscato  2 , Samantha Innocenti  1   4 , Elisa Buti  1 , Carmela Errichiello  1 , Marco Materassi  1 , Catia Olianti  3   5 , Lorenzo Masieri  3   6 , Francesca Becherucci  1   4
Affiliations

Early identification of CKD in patients with solitary functioning kidney

Luigi Cirillo et al. Nephrol Dial Transplant. .
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1:
Figure 1:
(A) Kaplan–Meier curves showing kidney injury-free survival in cSFK patients, grouped by renal length percentiles at referral: <50th, 50th–94th and >95th. Kidney injury includes proteinuria, hypertension, reduced eGFR or decreased function by RS. Time to injury was measured from start of follow-up to injury onset or last follow-up. Log-Rank test P = .6. (B) Rate of kidney injury diagnosis stratified by age group in patients with kidney length >50th percentile, highlighting the additional diagnostic yield of RS in patients with cSFK. The bars represent the proportion of patients diagnosed with kidney injury through RS alone (yellow), without other clinical signs of renal damage (e.g. reduced eGFR, hypertension or proteinuria) (red) and without kidney injury (green), demonstrating the incremental value of RS in uncovering subclinical kidney injury before other signs appear.
See this image and copyright information in PMC

References

    1. Cirillo L, De Chiara L, Innocenti S et al. Chronic kidney disease in children: an update. Clin Kidney J 2023;16:1600–11. 10.1093/ckj/sfad097 - DOI - PMC - PubMed
    1. Marzuillo P, Di Sessa A, Guarino S et al. Kidney injury and congenital solitary functioning kidney: more research efforts are needed. Kidney Int 2023;103:427–8. 10.1016/j.kint.2022.11.016 - DOI - PubMed
    1. Groen In ’t Woud S, Roeleveld N, Westland R et al. Uncovering risk factors for kidney injury in children with a solitary functioning kidney. Kidney Int 2023;103:156–65. 10.1016/j.kint.2022.09.028 - DOI - PubMed
    1. Matsell DG, Bao C, White TP et al. Kidney length standardized to body length predicts outcome in infants with a solitary functioning kidney. Pediatr Nephrol 2023;38:173–180. 10.1007/s00467-022-05544-y - DOI - PubMed
    1. Jawa NA, Rosenblum ND, Radhakrishnan S et al. Reducing unnecessary imaging in children with multicystic dysplastic kidney or solitary kidney. Pediatrics 2021;148:e2020035550. 10.1542/peds.2020-035550 - DOI - PubMed

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