Multi-center, international endometrial cancer consortium highlights

Luigi De Vitis¹, Anna Giudici², Vincenzo Tarantino³, Stuart Ostby¹, Kelly Bruce¹, Daniel Breitkopf¹, Alexander Olawaiye⁴, Ramez N Eskander⁵, Robert L Coleman⁶, Amir Momeni-Boroujeni⁷, Michael Deavers⁸, Maryam Shahi⁹, Giovanni Scambia¹⁰, Giorgia Dinoi¹⁰, Matthew Powell¹¹, John Weroha¹², Lora H Ellenson⁷, Behrouz Zand¹³, Amanika Kumar¹, Jessica Gorzelitz¹⁴, Jennifer Mueller¹⁵, Angelica Nogueira-Rodrigues¹⁶, Mario M Leitao Jr¹⁵, Karolina Kilowski¹³, Allison Garda¹⁷, Kaled Alektiar¹⁸, Evelyn Reynolds¹, Andrea E Wahner Hendrickson¹², David Mutch¹¹, Nadeem R Abu-Rustum¹⁵, Pedro T Ramirez¹³, Andrea Mariani¹, Gretchen E Glaser¹⁹

Affiliations

¹ Mayo Clinic, Department of Obstetrics and Gynecology, Rochester, MN, USA.
² Mayo Clinic, Department of Obstetrics and Gynecology, Rochester, MN, USA; University of Insubria Faculty of Medicine and Surgery, Department of Obstetrics and Gynecology, Varese, Italy.
³ Mayo Clinic, Department of Obstetrics and Gynecology, Rochester, MN, USA; Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Women, Children, and Public Health Sciences, Rome, Italy.
⁴ University of Pittsburgh School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Pittsburgh, PA, USA.
⁵ University of California, San Diego Moores Cancer Center, Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, La Jolla, CA, USA.
⁶ US Oncology Network, Texas Oncology, Gynecologic Oncology, The Woodlands, TX, USA.
⁷ Memorial Sloan Kettering Cancer Center, Department of Pathology and Laboratory Medicine, New York, NY, USA.
⁸ Houston Methodist Hospital, Department of Pathology, Houston, TX, USA.
⁹ Mayo Clinic, Department of Laboratory Medicine, Rochester, MN, USA.
¹⁰ Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Women, Children, and Public Health Sciences, Rome, Italy.
¹¹ Washington University School of Medicine, Division of Gynecologic Oncology, St Louis, MO, USA.
¹² Mayo Clinic, Department of Oncology, Rochester, MN, USA.
¹³ Houston Methodist Hospital, Department of Obstetrics and Gynecology, Houston, TX, USA.
¹⁴ University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
¹⁵ Memorial Sloan Kettering Cancer Center, Department of Surgery, New York, NY, USA.
¹⁶ Oncoclínicas, Latin American Cooperative Oncology Group (LACOG), Brazilian Group of Gynecologic Oncology (EVA), Federal University MG, DOM Oncologia, Brazil.
¹⁷ Mayo Clinic, Department of Radiation Oncology, Rochester, MN, USA.
¹⁸ Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology, New York, NY, USA.
¹⁹ Mayo Clinic, Department of Obstetrics and Gynecology, Rochester, MN, USA. Electronic address: glaser.gretchen@mayo.edu.

PMID: 40252598
DOI: 10.1016/j.ijgc.2025.101805

Multi-center, international endometrial cancer consortium highlights

Luigi De Vitis et al. Int J Gynecol Cancer. 2025 May.

. 2025 May;35(5):101805.

doi: 10.1016/j.ijgc.2025.101805. Epub 2025 Mar 29.

Authors

Affiliations

¹ Mayo Clinic, Department of Obstetrics and Gynecology, Rochester, MN, USA.
² Mayo Clinic, Department of Obstetrics and Gynecology, Rochester, MN, USA; University of Insubria Faculty of Medicine and Surgery, Department of Obstetrics and Gynecology, Varese, Italy.
³ Mayo Clinic, Department of Obstetrics and Gynecology, Rochester, MN, USA; Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Women, Children, and Public Health Sciences, Rome, Italy.
⁴ University of Pittsburgh School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Pittsburgh, PA, USA.
⁵ University of California, San Diego Moores Cancer Center, Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, La Jolla, CA, USA.
⁶ US Oncology Network, Texas Oncology, Gynecologic Oncology, The Woodlands, TX, USA.
⁷ Memorial Sloan Kettering Cancer Center, Department of Pathology and Laboratory Medicine, New York, NY, USA.
⁸ Houston Methodist Hospital, Department of Pathology, Houston, TX, USA.
⁹ Mayo Clinic, Department of Laboratory Medicine, Rochester, MN, USA.
¹⁰ Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Women, Children, and Public Health Sciences, Rome, Italy.
¹¹ Washington University School of Medicine, Division of Gynecologic Oncology, St Louis, MO, USA.
¹² Mayo Clinic, Department of Oncology, Rochester, MN, USA.
¹³ Houston Methodist Hospital, Department of Obstetrics and Gynecology, Houston, TX, USA.
¹⁴ University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
¹⁵ Memorial Sloan Kettering Cancer Center, Department of Surgery, New York, NY, USA.
¹⁶ Oncoclínicas, Latin American Cooperative Oncology Group (LACOG), Brazilian Group of Gynecologic Oncology (EVA), Federal University MG, DOM Oncologia, Brazil.
¹⁷ Mayo Clinic, Department of Radiation Oncology, Rochester, MN, USA.
¹⁸ Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology, New York, NY, USA.
¹⁹ Mayo Clinic, Department of Obstetrics and Gynecology, Rochester, MN, USA. Electronic address: glaser.gretchen@mayo.edu.

PMID: 40252598
DOI: 10.1016/j.ijgc.2025.101805

Abstract

The multi-center, international consortium on endometrial cancer held in January 2025 at Mayo Clinic in Rochester, Minnesota brought together leading experts in gynecologic oncology to explore the latest advancements in the understanding, diagnosis, and treatment of endometrial cancer. Discussions centered on key topics, including updates in molecular testing and disease staging, emerging treatment strategies for advanced and recurrent disease, fertility-sparing management, and critical pathology challenges, particularly, the assessment of lympho-vascular space invasion. Each topic was examined in dedicated working group sessions, fostering in-depth exchanges to identify research priorities and develop actionable strategies. This summary highlights the central themes and insights from the meeting, outlining a roadmap for future advancements in the field. By promoting inter-disciplinary collaboration, the meeting laid the foundation for future research, policy recommendations, and clinical innovations aimed at improving patient outcomes.

Keywords: Disease Staging; Endometrial Cancer; Fertility-Sparing Treatments; Lympho-vascular Space Invasion; Novel Therapies.

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Conflict of interest statement

Declaration of Competing Interests LDV is Early Career Editorial Board Member of the IJGC. RC, ML, and AM are Editorial Board Members of the IJGC. PR is the Editor-in-Chief of the IJGC. These authors had no involvement in the peer-review of this article and have no access to information regarding its peer review. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

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Multi-center, international endometrial cancer consortium highlights

Affiliations

Multi-center, international endometrial cancer consortium highlights

Authors

Affiliations

Abstract

Conflict of interest statement

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