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Review
. 2025 May 3;405(10489):1621-1632.
doi: 10.1016/S0140-6736(25)00354-X. Epub 2025 Apr 17.

Prolonged grief disorder

Affiliations
Review

Prolonged grief disorder

Clare Killikelly et al. Lancet. .

Abstract

Prolonged grief disorder is a mental health disorder recently included in diagnostic manuals worldwide. This Review presents published research evidence in strong support for the current conceptualisation of prolonged grief disorder: a diagnosable mental health condition with core symptoms of yearning, preoccupation, or both, which is associated with symptoms of emotional pain, identity disturbances, loss of meaning and purpose, and functional impairment. The public and academic discourse surrounding prolonged grief disorder has catalysed researchers to produce methodologically rigorous research evidence in support of this much-needed diagnosis. A coherent syndrome of prolonged grief disorder has a typical onset of 6 to 12 months after the death of a close person. Prolonged grief disorder is associated with various poor outcomes, including negative health outcomes (eg, high blood pressure), increased rates of suicidality, low life satisfaction, and increased service use. Psychotherapy is the main treatment for prolonged grief disorder. Theoretical models of the cause and maintenance of prolonged grief disorder are presently being refined through the rapidly increasing empirical literature. Awareness of prolonged grief disorder by general health practitioners, as well as mental health specialists, is key to appropriate early intervention.

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Conflict of interest statement

Declaration of interests CK is supported by the Swiss National Science Foundation Starting Grant (TMSGI1_218018). KVS is supported by the Medical Research Council (MR/V001841/1) and the National Institute for Health and Care Research (NIHR) Oxford Health Biomedical Research Centre (NIHR203316). HGP is supported by the National Cancer Institute (CA197730). All other authors declare no competing interests. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.

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