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. 1985 Aug;21(4):771-5.
doi: 10.1002/ajmg.1320210421.

Reduction of fragile X expression in blood after cryopreservation

K Shimanuki, M S Lin, M G Wilson

Reduction of fragile X expression in blood after cryopreservation

K Shimanuki et al. Am J Med Genet. 1985 Aug.

Abstract

Frequency of fragile X expression was investigated before and after cryopreservation (-196 degrees C) in the blood of 4 affected males, 3 fragile X carriers and in a fibroblast cell strain from a fragile X male fetus. The results indicate that there is a significant decrease (p less than 0.05) in the frequency of the fragile X expression in lymphocytes after cryopreservation, as compared to the fresh blood, but not in fibroblasts. This suggests that cryopreserved blood specimens may not be suitable for fragile X analysis.

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