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Review
. 2025 Aug;29(4):557-567.
doi: 10.1111/1744-9987.70023. Epub 2025 Apr 20.

Therapeutic plasma apheresis for IgA vasculitis-related gastrointestinal bleeding

Yuri Shinotsuka  1 , Kensei Taguchi  1   2 , Goh Kodama  1 , Ryo Shibata  1 , Kei Fukami  1
Affiliations
Review

Therapeutic plasma apheresis for IgA vasculitis-related gastrointestinal bleeding

Yuri Shinotsuka et al. Ther Apher Dial. 2025 Aug.

Abstract

Introduction: Adult-onset IgA vasculitis (IgAV) often presents with severe renal and gastrointestinal (GI) complications, yet therapeutic guidelines for life-threatening manifestations remain unclear.

Methods: We conducted a systematic text-mining analysis of all PubMed-indexed case reports of IgAV treated with therapeutic plasma exchange (TPE).

Results: We describe an 80-year-old woman with refractory GI bleeding and rapidly progressive glomerulonephritis. Despite high-dose corticosteroids and cyclophosphamide, GI bleeding persisted and necessitated multiple transcatheter embolization. A total of seven sessions of TPE using fresh frozen plasma successfully controlled disease activity, resulting in improvement of GI bleeding. Literature review suggests that TPE may provide additive benefits in IgAV patients, particularly in those unresponsive to standard immunosuppressants.

Conclusion: This case supports the utility of TPE as a valuable adjunctive therapy in severe IgAV with organ-threatening manifestations and highlights the need for further studies to define optimal indications.

Keywords: IgA vasculitis; aneurysm; gastrointestinal bleeding; therapeutic plasma apheresis.

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References

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