The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs: A multicenter retrospective real-world study

Zijie Xu¹, Chujiang He¹, Jianwei Cao^{2

3}, Jianhong Wu^{3

4}, Dawei Wang^{3

5}, Jun Da^{3

6}, Dongliang Xu^{3

7}, Mingyue Tan^{3

7}, Xiaofeng Gao^{3

8}, Yonghan Peng^{3

8}, Jie Chen^{3

9}, Rong Chen^{3

10}, Pengfei Wu^{3

11}, Juntao Jiang¹, Lei Chen¹, Shujie Xia^{1

3}, Yi Shao^{1

3}

Affiliations

¹ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Urology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Shanghai Municipal Hospital Urology Specialist Alliance, Shanghai, China.
⁴ Department of Urology, Huadong Hospital, Fudan University, Shanghai, China.
⁵ Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁷ Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁸ Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China.
⁹ Department of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
¹⁰ Department of Urology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
¹¹ Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

PMID: 40256287
PMCID: PMC12004964
DOI: 10.1097/CU9.0000000000000250

The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs: A multicenter retrospective real-world study

Zijie Xu et al. Curr Urol. 2024 Dec.

. 2024 Dec;18(4):283-286.

doi: 10.1097/CU9.0000000000000250. Epub 2024 Jun 11.

Authors

Affiliations

¹ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Urology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Shanghai Municipal Hospital Urology Specialist Alliance, Shanghai, China.
⁴ Department of Urology, Huadong Hospital, Fudan University, Shanghai, China.
⁵ Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁷ Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁸ Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China.
⁹ Department of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
¹⁰ Department of Urology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
¹¹ Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

PMID: 40256287
PMCID: PMC12004964
DOI: 10.1097/CU9.0000000000000250

Abstract

Objective: The objective of this study is to assess the effectiveness and safety of ureteroscopic lithotripsy and flexible ureteroscopy (fURS) for treating patients on anticoagulant (AC) or antiplatelet (AP) medications.

Patients and methods: The study included 213 patients with urinary stones who underwent ureteroscopic lithotripsy or fURS between January 2019 and October 2022 at the Shanghai Municipal Hospital Urology Specialist Alliance. Among these patients, 15 received AC therapy, 193 received AP therapy, and 5 received both AC and AP therapy. Patients were divided into 3 groups based on the real-world management of antithrombotic drugs: the continuation group (n = 62), the discontinuation group (n = 91), and the discontinuation and bridge heparin group (n = 60). Intraoperative and postoperative outcomes were compared among the 3 groups.

Results: Age, sex, body mass index, stone location, stone size, stone side, and residual fragments were not different among the groups. None of the patients received blood transfusions or had thromboembolic events, emergencies for gross hematuria, significant bleeding-related complications, or unplanned secondary ureteroscopic surgery. The mean duration of hospital stay of the continuation group (3.97 days) was significantly lower than that of the discontinuation group (5.99 days) and the discontinuation and bridge heparin group (5.75 days) (p < 0.001).

Conclusions: Ureteroscopic lithotripsy and fURS can be performed safely and effectively in patients on AC or AP drugs, resulting in reduced duration of hospital stay.

Keywords: Anticoagulant drugs; Antiplatelet drugs; Flexible ureteroscopy; Ureteroscopic lithotripsy.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

References

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The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs: A multicenter retrospective real-world study

Affiliations

The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs: A multicenter retrospective real-world study

Authors

Affiliations

Abstract

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources