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. 2025 Aug 1;46(29):2924-2927.
doi: 10.1093/eurheartj/ehaf260.

Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy

Christos P Kotanidis  1   2 , Thomas Halborg  1 , Pete Tomlins  3 , Kenneth Chan  1 , Sam Fry  3 , Gaëlle Jimenez  4 , Matthieu Lapeyre  5 , Nikant Sabharwal  6 , Keith M Channon  1   6 , Stefan Neubauer  1   6 , Sophie Jacob  7 , Charalambos Antoniades  1   6
Affiliations

Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy

Christos P Kotanidis et al. Eur Heart J. .
No abstract available

Keywords: Biomarkers; Cardio-oncology; Cardiovascular risk; Computed tomography imaging; Coronary inflammation; Radiotherapy.

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Figures

Figure 1
Figure 1
(A) Table of demographics for the study participants. (B) Calcium score was significantly increased 2 years after radiotherapy. Fat Attenuation Index Score (presented as percentiles on age and sex-specific nomograms) was significantly reduced 2 years after radiotherapy, suggesting reduction of coronary inflammation. The AI-Risk (8-year risk for cardiac mortality calculated by incorporating FAI Score, plaque burden and patient risk factors) was also significantly reduced 2 years after radiotherapy. (C) There was no correlation between delta-AI-Risk and delta serum high-sensitivity C-reactive protein from baseline to follow-up. (D) There was no change in the total non-calcified plaque volume between baseline (before radiotherapy) to follow-up (2 years after radiotherapy). (E) Alluvial plot of risk re-classification based on the AI-Risk classification system; (F) Example of the changes in perivascular fat attenuation index map around the proximal left anterior descending artery in a 50-year-old female patient with no history of cardiovascular disease. Values presented as mean ± SEM, and P-values derived by paired t-test or the Wilcoxon signed-rank test as appropriate; The values in the scatterplot have been transformed using the following formula: sqrt(variable − min(variable) + 1) and the P-value was derived by the Spearman’s rho test
See this image and copyright information in PMC

References

    1. Halle M, Gabrielsen A, Paulsson-Berne G, Gahm C, Agardh HE, Farnebo F, et al. Sustained inflammation due to nuclear factor-kappa B activation in irradiated human arteries. J Am Coll Cardiol 2010;55:1227–36. 10.1016/j.jacc.2009.10.047 - DOI - PubMed
    1. Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 2013;368:987–98. 10.1056/NEJMoa1209825 - DOI - PubMed
    1. Vallis KA, Pintilie M, Chong N, Holowaty E, Douglas PS, Kirkbride P, et al. Assessment of coronary heart disease morbidity and mortality after radiation therapy for early breast cancer. J Clin Oncol 2002;20:1036–42. 10.1200/JCO.2002.20.4.1036 - DOI - PubMed
    1. Honaryar MK, Allodji R, Jimenez G, Lapeyre M, Panh L, Camilleri J, et al. Early development of atherosclerotic plaques in the coronary arteries after radiotherapy for breast cancer (BACCARAT study). J Cardiovasc Dev Dis 2023;10:299. 10.3390/jcdd10070299 - DOI - PMC - PubMed
    1. Oikonomou EK, Antonopoulos AS, Schottlander D, Marwan M, Mathers C, Tomlins P, et al. Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device. Cardiovasc Res 2021;117:2677–90. 10.1093/cvr/cvab286 - DOI - PubMed