Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 7;80(5):glaf021.
doi: 10.1093/gerona/glaf021.

Workshop Report-Heterogeneity and Successful Aging Part II: Approaches to Investigate Heterogeneity in Aging Research

Vivek Kumar  1 , Andrea L Hevener  2   3 , J Graham Ruby  4 , Paola Sebastiani  5   6 , George A Kuchel  7 ; Participants of the NIA Heterogeneity and Successful Aging Workshop
Collaborators, Affiliations

Workshop Report-Heterogeneity and Successful Aging Part II: Approaches to Investigate Heterogeneity in Aging Research

Vivek Kumar et al. J Gerontol A Biol Sci Med Sci. .

Abstract

Heterogeneity in aging is a fundamental biological process arising from multifactorial etiologies, including genetic, lifestyle, and socioeconomic factors. Modeling this heterogeneity in animal systems is critical for elucidating the underlying mechanisms of aging and for leveraging these insights in translational research. Here we present part II, a summary of the model organism research presented at the NIA Heterogeneity and Successful Aging workshop, held in May 2023.

Keywords: Age-related pathology; Animal model; Anti-aging; Biodemography; Bioinformatics; Biology of aging; Frailty.

PubMed Disclaimer

Conflict of interest statement

The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the United States Government.

References

    1. Mitchell SJ, Scheibye-Knudsen M, Longo DL, Cabo R de.. Animal models of aging research: implications for human aging and age-related diseases. Annu Rev Anim Biosci. 2015;3:283–303. https://doi.org/ 10.1146/annurev-animal-022114-110829 - DOI - PubMed
    1. Rowe JW, Kahn RL.. Human aging: usual and successful. Science. 1987;237(4811):143–149. https://doi.org/ 10.1126/science.3299702 - DOI - PubMed
    1. Maddox GL, Douglass EB.. Aging and individual differences: a longitudinal analysis of social, psychological, and physiological indicators. J Gerontol. 1974;29(5):555–563. https://doi.org/ 10.1093/geronj/29.5.555 - DOI - PubMed
    1. Nelson EA, Dannefer D.. Aged heterogeneity: fact or fiction? The fate of diversity in gerontological research. Gerontologist. 1992;32(1):17–23. https://doi.org/ 10.1093/geront/32.1.17 - DOI - PubMed
    1. Yang Y, Lee LC.. Dynamics and heterogeneity in the process of human frailty and aging: evidence from the U.S. Older Adult Population. J Gerontol. Series B, Psychol Sci Soc Sci. 2010;65B(2):246–255. https://doi.org/ 10.1093/geronb/gbp102 - DOI - PMC - PubMed