Integrin Targeting Therapies in Pulmonary Arterial Hypertension: A Roadmap for Traversing the Translational Valley of Death?

Vineet Agrawal^{1

2

3}, Anna R Hemnes^{1

4}

Affiliations

¹ Pulmonary Circulation Center (V.A., A.R.H.), Vanderbilt University Medical Center, Nashville, TN.
² Division of Cardiovascular Medicine (V.A.), Vanderbilt University Medical Center, Nashville, TN.
³ Department of Veterans Affairs, Nashville, TN (V.A.).
⁴ Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN (A.R.H.).

PMID: 40258053
PMCID: PMC12014143 (available on 2026-04-22)
DOI: 10.1161/CIRCULATIONAHA.125.074059

Editorial

Integrin Targeting Therapies in Pulmonary Arterial Hypertension: A Roadmap for Traversing the Translational Valley of Death?

Vineet Agrawal et al. Circulation. 2025.

. 2025 Apr 22;151(16):1184-1186.

doi: 10.1161/CIRCULATIONAHA.125.074059. Epub 2025 Apr 21.

Authors

Vineet Agrawal^{1

2

3}, Anna R Hemnes^{1

4}

Affiliations

¹ Pulmonary Circulation Center (V.A., A.R.H.), Vanderbilt University Medical Center, Nashville, TN.
² Division of Cardiovascular Medicine (V.A.), Vanderbilt University Medical Center, Nashville, TN.
³ Department of Veterans Affairs, Nashville, TN (V.A.).
⁴ Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN (A.R.H.).

PMID: 40258053
PMCID: PMC12014143 (available on 2026-04-22)
DOI: 10.1161/CIRCULATIONAHA.125.074059

No abstract available

Keywords: Editorials; familial primary pulmonary hypertension; pulmonary arterial hypertension.

PubMed Disclaimer

Conflict of interest statement

A.R.H. reports consulting arrangements for GossmerBio, United Therapeutics, Johnson and Johnson, and Merck. She holds stock in Tenax Therapeutics. The other author reports no conflicts.

Comment on

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies.
Lemay SE, Montesinos MS, Grobs Y, Yokokawa T, Shimauchi T, Mougin M, Romanet C, Sauvaget M, Breuils-Bonnet S, Bourgeois A, Théberge C, Pelletier A, El Kabbout R, Martineau S, Yamamoto K, Akram M, Ray AS, Lippa B, Goodwin B, Lin FY, Wang H, Dowling JE, Lu M, Qiao Q, McTeague TA, Moy TI, Potus F, Provencher S, Boucherat O, Bonnet S. Lemay SE, et al. Circulation. 2025 Apr 22;151(16):1162-1183. doi: 10.1161/CIRCULATIONAHA.124.070693. Epub 2025 Jan 20. Circulation. 2025. PMID: 39829438 Free PMC article.

References

1. Humbert M, Lau EM, Montani D, Jais X, Sitbon O, Simonneau G. Advances in therapeutic interventions for patients with pulmonary arterial hypertension. Circulation. 2014;130:2189–2208. doi: 10.1161/CIRCULATIONAHA.114.006974 - DOI - PubMed
1. Sahay S, Chakinala MM, Kim NH, Preston IR, Thenappan T, McLaughlin VV. Contemporary Treatment of Pulmonary Arterial Hypertension: A U.S. Perspective. Am J Respir Crit Care Med. 2024;210:581–592. doi: 10.1164/rccm.202405-0914SO - DOI - PubMed
1. Chang KY, Duval S, Badesch DB, Bull TM, Chakinala MM, De Marco T, Frantz RP, Hemnes A, Mathai SC, Rosenzweig EB, et al. Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry. J Am Heart Assoc. 2022;11:e024969. doi: 10.1161/JAHA.121.024969 - DOI - PMC - PubMed
1. Coller BS, Califf RM. Traversing the valley of death: a guide to assessing prospects for translational success. Sci Transl Med. 2009;1:10cm19. doi: 10.1126/scitranslmed.3000265 - DOI - PMC - PubMed
1. Galkina Cleary E, Jackson MJ, Zhou EW, Ledley FD. Comparison of Research Spending on New Drug Approvals by the National Institutes of Health vs the Pharmaceutical Industry, 2010–2019. JAMA Health Forum. 2023;4:e230511. doi: 10.1001/jamahealthforum.2023.0511 - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Integrin Targeting Therapies in Pulmonary Arterial Hypertension: A Roadmap for Traversing the Translational Valley of Death?

Affiliations

Integrin Targeting Therapies in Pulmonary Arterial Hypertension: A Roadmap for Traversing the Translational Valley of Death?

Authors

Affiliations

Conflict of interest statement

Comment on

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources